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21 November 2022: Clinical Research

Long-Term Effect of Pancreaticoduodenectomy Combined with Revascularization for Resectable Pancreatic Carcinoma in Elderly Patients

Jiali Yang 1ABCDEF* , Zhengrong Xu 2ABCD* , Junfeng Zhang 1CD , Yao Zheng 1CD , Jianyou Gu 1AC , Qiang Zhou 1CD , Xianxing Wang 1CD , Shixiang Guo 1DF , Hongyu Zhang 3AD , Shengkai Chen 1ADG* , Huaizhi Wang 1ADG*

DOI: 10.12659/MSM.938443

Med Sci Monit 2022; 28:e938443

Table 2 Perioperative and pathologic characteristics of the PDAC patients who underwent PDR according to age.

VariablesTotal (n=185)Age <60 y (n=103)60 y ≤ Age <70 y (n=55)Age ≥70 y (n=27)P value
Type of PD* 0.851
 PPPD29 (15.7)15 (14.6)10 (18.2)4 (14.8)
 Whipple156 (83.3)88 (85.4)45 (81.8)23 (85.2)
Vascular invasion site* 0.755
 PV23 (12.4)12 (11.7)7 (12.7)4 (14.8)
 Confluence of SMV and PV83 (44.9)48 (46.6)26 (47.3)9 (33.3)
 SMV79 (42.7)43 (41.7)22 (40.0)14 (51.9)
Types of venous reconstruction* 0.073
 Interposition graft70 (37.8)44 (42.7)22 (40.0)4 (14.8)
 End-to-end anastomosis101 (54.6)51 (49.5)30 (54.5)20 (74.1)
 Primary closure14 (7.6)8 (7.8)3 (5.5)3 (11.1)
Ligation of splenic vein* 26 (14.1)16 (15.5)6 (10.9)4 (14.8)0.764
Combined organ resection* 11 (5.9)6 (5.8)2 (3.6)3 (11.1)0.386
Operation duration (min)** 460 (178–960)470 (245–960)458 (277–814)410 (178–640)0.063
Operative blood loss (ml)** 600 (200–7200)600 (200–7200)600 (200–4000)600 (200–1700)0.566
Operative blood transfusion (ml)** 400 (0–3500)400 (0–3500)300 (0–2550)400 (0–1200)0.689
Postoperative hospital stay (days)** 20 (5–164)21 (5–164)19 (8–36)19 (6–42)0.246
ICU stay (days)** 3 (1–90)3 (1–90)3 (1–25)3 (2–13)0.035
Tumor size (cm)** 3 (2.1–4.0)3 (2.1–4.0)3 (3.0–3.5)3.5 (2.5–4.0)0.588
Degree of differentiation* 0.783
 Well14 (7.6)5 (4.9)3 (5.5)13 (48.1)
 Moderate130 (70.3)78 (75.7)39 (70.9)13 (48.1)
 Poor41 (22.2)20 (19.4)13 (23.6)8 (29.6)
Pathological invasion of PV-SMV* 38 (20.5)17 (16.5)12 (21.8)9 (33.3)0.150
Neurological invasion* 90 (48.6)55 (53.4)22 (40.0)13 (48.1)0.275
Resection margin* 0.505
 R0176 (95.1)98 (95.1)51 (92.7)51 (92.7)
 R19 (4.9)5 (4.9)4 (7.3)0
TNM staging* 0.837
 I105 (56.8)55 (53.3)34 (61.8)16 (59.3)
 II57 (30.8)34 (33.0)15 (27.3)8 (29.6)
 III13 (7.0)9 (8.7)2 (3.6)2 (7.4)
 IV10 (5.4)5 (4.9)4 (7.3)1 (3.7)
T staging* 0.346
 T141 (22.1)22 (21.3)14 (25.5)5 (18.5)
 T2109 (58.9)56 (54.3)33 (60.0)20 (74.0)
 T330 (16.2)22 (21.3)6 (10.9)2 (7.4)
 T45 (2.7)3 (2.9)2 (3.6)0
N staging* 0.267
 N0131 (70.8)72 (59.9)42 (76.4)17 (63.0)
 N144 (23.8)23 (22.3)13 (23.6)8 (29.6)
 N210 (5.4)8 (7.8)02 (7.4)
Distant metastasis* 10 (5.4)5 (4.9)4 (7.3)1 (3.7)0.900
* Results are presented as a number (percentage);
** results are presented as the median (range).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750