21 November 2022: Clinical Research
Long-Term Effect of Pancreaticoduodenectomy Combined with Revascularization for Resectable Pancreatic Carcinoma in Elderly Patients
Jiali Yang 1ABCDEF* , Zhengrong Xu 2ABCD* , Junfeng Zhang 1CD , Yao Zheng 1CD , Jianyou Gu 1AC , Qiang Zhou 1CD , Xianxing Wang 1CD , Shixiang Guo 1DF , Hongyu Zhang 3AD , Shengkai Chen 1ADG* , Huaizhi Wang 1ADG*DOI: 10.12659/MSM.938443
Med Sci Monit 2022; 28:e938443
Table 3 Postoperative complications of stays the PDAC patients who underwent PDR according to age.
| Variables | Total (n=185) | Age <60 y (n=103) | 60 y ≤ Age <70 y (n=55) | Age ≥70 y (n=27) | P value |
|---|---|---|---|---|---|
| Clavien-Dindo classification | 114 (61.6) | 63 (61.2) | 34 (61.8) | 17 (63.0) | 0.985 |
| I | 29 (15.7) | 15 (14.6) | 11 (20.0) | 3 (11.1) | |
| II | 56 (30.3) | 35 (34.0) | 16 (29.1) | 5 (18.5) | |
| III | 12 (6.5) | 7 (6.8) | 4 (7.3) | 1 (3.7) | |
| IV | 13 (7.0) | 5 (4.9) | 1 (1.8) | 7 (25.9) | |
| V | 4 (2.2) | 1 (1.0) | 2 (3.6) | 1 (3.7) | |
| Grade of complication ≥III | 29 (15.8) | 13 (12.6) | 7 (12.7) | 9 (33.3) | 0.043 |
| Pancreatic fistula | 15 (8.1) | 9 (8.7) | 4 (7.3) | 2 (7.4) | 1.000 |
| Grade A | 7 (3.9) | 4 (3.9) | 2 (3.6) | 1 (3.7) | |
| Grade B | 3 (1.6) | 2 (1.9) | 1 (1.8) | 0 | |
| Grade C | 4 (2.2) | 3 (2.9) | 1 (1.8) | 1 (3.7) | |
| Non-pancreatic anastomotic leakage | 11 (5.9) | 9 (8.7) | 2 (3.6) | 0 | 0.227 |
| Biliary anastomotic leakage | 7 (3.8) | 6 (5.8) | 1 (1.8) | 0 | |
| Gastrointestinal anastomotic leakage | 4 (2.2) | 3 (2.9) | 1 (1.8) | 0 | |
| Lymphatic leakage | 6 (3.2) | 5 (4.8) | 0 | 1 (3.7) | 0.229 |
| Delayed gastric emptying | 21 (11.4) | 13 (12.6) | 7 (12.7) | 1 (3.7) | 0.495 |
| Grade A | 7 (3.9) | 3 (2.9) | 3 (5.5) | 1 (3.7) | |
| Grade B | 9 (4.9) | 8 (7.8) | 1 (1.8) | 0 | |
| Grade C | 5 (2.7) | 2 (1.9) | 3 (5.5) | 0 | |
| Post-pancreatectomy hemorrhage | 30 (16.2) | 17 (16.5) | 10 (18.2) | 3 (11.1) | 0.787 |
| Grade A | 10 (5.4) | 6 (5.8) | 4 (7.3) | 0 | |
| Grade B | 3 (1.6) | 1 (1.0) | 2 (3.6) | 0 | |
| Grade C | 17 (9.2) | 10 (9.7) | 4 (7.3) | 3 (11.1) | |
| Gastrointestinal hemorrhage | 22 (11.9) | 13 (12.6) | 8 (14.5) | 1 (3.7) | 0.352 |
| Intraperitoneal hemorrhage | 15 (8.1) | 9 (8.7) | 3 (5.5) | 3 (11.1) | 0.562 |
| Hepatic ischemia–reperfusion injury | 26 (14.1) | 18 (17.5) | 5 (9.1) | 3 (11.1) | 0.369 |
| Blood transfusion for non-hemorrhagic anemia | 25 (13.5) | 14 (13.6) | 7 (12.7) | 4 (14.8) | 1.000 |
| Thoracic or abdominal puncture and drainage | 13 (7.0) | 10 (9.7) | 2 (3.6) | 1 (3.7) | 0.402 |
| Organ dysfunction | 17 (9.2) | 6 (5.8) | 3 (5.5) | 8 (29.6) | 0.002 |
| MODS | 7 (3.8) | 3 (2.9) | 3 (5.5) | 1 (3.7) | |
| Single-organ dysfunction | 10 (5.4) | 3 (2.9) | 0 | 7 (25.9) | |
| Infections | 51 (27.6) | 27 (26.2) | 13 (23.6) | 11 (40.7) | 0.239 |
| Pulmonary infection | 25 (13.5) | 9 (8.7) | 6 (10.9) | 10 (37.0) | 0.002 |
| Intraperitoneal infection | 28 (15.1) | 19 (18.4) | 6 (10.9) | 3 (11.1) | 0.410 |
| Re-laparotomy | 19 (10.3) | 11 (0.7) | 5 (9.1) | 3 (11.1) | 1.000 |
| Mortality (90 d) | 15 (8.1) | 6 (5.8) | 4 (7.3) | 5 (18.5) | 0.095 |
| Results are presented as a number (percentage); MODS – multiple organ dysfunction syndromes. | |||||