Association Between Neutrophil-Lymphocyte Ratio and All-Cause Mortality in Critically Ill Patients with Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study

14 February 2023: Database Analysis

Shujie Hao ^1ABCDEF , Yamei Yuan ^1BDEG , Weidong Ye ^2BCD , Xiangming Fang ^2AEFG*

DOI: 10.12659/MSM.938554

Med Sci Monit 2023; 29:e938554

Table 2 HRs (95% CIs) for mortality across groups of neutrophil-lymphocyte ratio.

	Model I (non-adjusted)			Model II			Model III
	HR (95% CI)	P value	P trend	HR (95% CI)	P value	P trend	HR (95% CI)	P value	P trend

Quartiles									0.003
Q1	1 (Ref)			1 (Ref)			1 (Ref)
Q2	1.48 (1.02~2.14)	0.037		1.41 (0.98~2.04)	0.068		1.4 (0.95~2.04)	0.085
Q3	1.94 (1.37~2.76)			1.8 (1.27~2.57)	0.001		1.51 (1.04~2.18)	0.028
Q4	2.79 (2~3.9)			2.62 (1.87~3.67)			1.75 (1.21~2.52)	0.003

Quartiles									0.002
Q1	1 (Ref)			1 (Ref)			1 (Ref)
Q2	1.44 (1.02~2.05)	0.04		1.36 (0.96~1.94)	0.085		1.36 (0.95~1.96)	0.094
Q3	1.87 (1.34~2.61)			1.72 (1.23~2.41)	0.001		1.49 (1.05~2.11)
Q4	2.69 (1.96~3.69)			2.5 (1.82~3.43)			1.71 (1.22~2.42)	0.002

Quartiles									0.002
Q1	1 (Ref)			1 (Ref)			1 (Ref)
Q2	1.23 (0.89~1.7)	0.219		1.17 (0.84~1.62)	0.35		1.19 (0.85~1.67)	0.302
Q3	1.7 (1.26~2.31)	0.001		1.57 (1.16~2.14)			1.42 (1.03~1.95)
Q4	2.36 (1.77~3.15)			2.19 (1.64~2.93)			1.59 (1.16~2.19)	0.004
HR – hazard ratio; CI – confidence interval. Models were derived from Cox regression models. non-adjusted. adjusted for: age; sex; race. adjusted for: age; sex; race; diabetes; hypertension; liver disease; renal disease; malignant cancer; platelets; WBC; anion gap; bicarbonate; BUN; chloride; creatinine; potassium; lactate; heart rate; mbp; respiratory rate; temperature; spo2; glucose; sofa; sapsii.