11 March 2023>: Database Analysis
Prognostic-Related Biomarkers in Pancreatic Ductal Adenocarcinoma Correlating with Immune Infiltrates Based on Proteomics
Yan-qi Kou 1ACEF* , Yu-ping Yang 1BCE* , Zhao-jie Pan 2E* , Shen-shen Du 1BC* , Wei-nan Yuan 1BC , Kun He 1E , Biao Nie 1A*DOI: 10.12659/MSM.938785
Med Sci Monit 2023; 29:e938785
Table 2 Univariate and multivariate analysis of OS in patients with PDAC.
Characteristics | Total (N) | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
Gender | |||||
Male vs Female | 125 | 1.211 (0.780–1.880) | 0.393 | ||
Tumor grade | |||||
G1–2 vs G3–4 | 125 | 1.526 (0.867–2.687) | 0.143 | ||
Tumor stage | |||||
Stage I–II vs stage III–IV | 125 | 1.790 (1.143–2.801) | 1.699 (1.066–2.709) | ||
Age (years) | |||||
125 | 1.118 (0.722–1.732) | 0.616 | |||
PLG expression | |||||
High vs Low | 125 | 1.720 (1.055–2.805) | 1.952 (1.134–3.360) | ||
COPS5 expression | |||||
High vs Low | 125 | 2.172 (1.345–3.507) | 1.904 (1.141–3.177) | ||
EPB42 expression | |||||
High vs Low | 125 | 1.712 (1.096–2.676) | 1.816 (0.731–4.510) | 0.199 | |
FYN expression | |||||
High vs Low | 125 | 0.668 (0.423–1.057) | 0.537 (0.322–0.896) | ||
ITGB3 expression | |||||
High vs Low | 125 | 1.851 (1.187–2.886) | 2.044 (1.182–3.533) | ||
SLC4A1 expression | |||||
High vs Low | 125 | 1.792 (1.020–3.149) | 1.451 (0.697–3.019) | 0.319 | |
IRF3 expression | |||||
High vs Low | 125 | 0.420 (0.251–0.705) | 0.500 (0.281–0.887) | ||
SPTA1 expression | |||||
High vs Low | 125 | 1.513 (0.978–2.343) | 0.063 | 0.379 (0.159–0.900) | |
The parameters from our cohort, including gender, tumor grade, tumor stage, age, and PLG, COPS5, EPB42, FYN, ITGB3, SLC4A1, IRF3, SPTA1 expression in PDAC were used for univariate Cox regression analyses and significant factors (P |