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11 March 2023: Database Analysis

Prognostic-Related Biomarkers in Pancreatic Ductal Adenocarcinoma Correlating with Immune Infiltrates Based on Proteomics

Yan-qi Kou 1ACEF* , Yu-ping Yang 1BCE* , Zhao-jie Pan 2E* , Shen-shen Du 1BC* , Wei-nan Yuan 1BC , Kun He 1E , Biao Nie 1A*

DOI: 10.12659/MSM.938785

Med Sci Monit 2023; 29:e938785

Table 2 Univariate and multivariate analysis of OS in patients with PDAC.

CharacteristicsTotal (N)Univariate analysisMultivariate analysis
Hazard ratio (95% CI)P valueHazard ratio (95% CI)P value
 Male vs Female1251.211 (0.780–1.880)0.393
Tumor grade
 G1–2 vs G3–41251.526 (0.867–2.687)0.143
Tumor stage
 Stage I–II vs stage III–IV1251.790 (1.143–2.801)1.699 (1.066–2.709)
Age (years)
1251.118 (0.722–1.732)0.616
PLG expression
 High vs Low1251.720 (1.055–2.805)1.952 (1.134–3.360)
COPS5 expression
 High vs Low1252.172 (1.345–3.507)1.904 (1.141–3.177)
EPB42 expression
 High vs Low1251.712 (1.096–2.676)1.816 (0.731–4.510)0.199
FYN expression
 High vs Low1250.668 (0.423–1.057)0.537 (0.322–0.896)
ITGB3 expression
 High vs Low1251.851 (1.187–2.886)2.044 (1.182–3.533)
SLC4A1 expression
 High vs Low1251.792 (1.020–3.149)1.451 (0.697–3.019)0.319
IRF3 expression
 High vs Low1250.420 (0.251–0.705)0.500 (0.281–0.887)
SPTA1 expression
 High vs Low1251.513 (0.978–2.343)0.0630.379 (0.159–0.900)
The parameters from our cohort, including gender, tumor grade, tumor stage, age, and PLG, COPS5, EPB42, FYN, ITGB3, SLC4A1, IRF3, SPTA1 expression in PDAC were used for univariate Cox regression analyses and significant factors (P

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750