Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

21 May 2023: Clinical Research

Value of IL-1β and IL-23 in Predicting 28-Day Mortality Due to Sepsis: A Retrospective Study

Jing Cao ABE* , Wenguang Liu CDE , Yong Li ABF , Bin Chen CDE , Tingfeng Yu DEF , Zhengbing He BCD , Yanke Hong EF

DOI: 10.12659/MSM.940163

Med Sci Monit 2023; 29:e940163

Table 1 Comparison of clinical indicators in the septic patients, ICU controls, and healthy controls.

Healthy controls (n=50)ICU controls (n=45)Septic patients (n=74)Z/χ2P value
 Age, years [median (IQR)]54.5 (45.5–67.0)61.0 (52.5–68.0)56.0 (43.0–68.0)2.8780.237
 Male sex (n, %)29 (58.00%)29 (64.44%)55 (74.32%)3.7510.153
 Urinary stones12 (26.67%)21 (28.38%)0.0410.840
 Cerebral vascular disease7 (15.56%)18 (24.32%)1.2970.255
 Diabetes mellitus8 (17.78%)9 (12.16%)0.7210.396
 Hypertension14 (34.11%)25 (33.78%)0.0910.763
 Hypoproteinemia16 (35.56%)18 (24.32%)1.7300.188
 Temperature, °C36.50 (36.30–36.60)36.50 (36.38–36.70)−0.7440.457
 Breath rate, beats/min20.00 (20.00–21.00)20.00 (20.00–21.00)−0.7850.432
 Heart rate, beats/min89.00 (79.00–100.00)87.00 (75.50–100.00)−0.8580.391
 SBP, mmHg107.00 (98.00–115.00)110.00 (98.00–122.00)−1.6590.097
 DBP, mmHg68.00 (62.00–75.00)70.00 (63.00–79.25)−0.9100.363
 White blood cells, ×10/L5.80 (4.88–7.14)11.15 (7.67–15.31)a 12.04 (8.96–16.69)a 55.097
 Neutrophils, ×10/L3.35 (2.83–4.30)9.20 (6.27–13.90)a 10.45 (6.82–14.72)a 69.155
 Lymphocytes, ×10/L1.87 (1.51–2.29)0.81 (0.48–1.01)a 0.72 (0.47–1.16)a 78.375
 Monocytes, ×10/L0.35 (0.26–0.44)0.65 (0.46–0.93)a 0.55 (0.31–0.86)a 21.954
 Hematocrit, %43.30 (41.23–46.48)33.70 (28.65–40.35)35.35 (23.30–41.23)a 41.159
 Platelets, ×10/L245.50 (197.50–262.50)171.00 (128.50–266.00)a 158.00 (128.50–219.75)a 20.185
 Creatinine, μmol/L67.00 (56.50–110.00)98.50 (62.75–177.50)b −2.9160.004
 Blood urea nitrogen, mmol/L6.44 (4.75–10.62)8.90 (5.72–15.05)b −2.2880.022
 Uric acid, μmol/L260.00 (197.50–360.50)269.50 (136.75–452.25)−0.1120.911
 Total bilirubin, μmol/L13.70 (8.40–21.55)20.20 (13.30–33.70)b −3.507
 Partial pressure of oxygen, mmHg87.00 (73.00–96.00)85.50 (65.00–108.00)−0.2080.835
 Partial pressure of carbon dioxide, mmHg35.00 (31.00–38.50)36.00 (32.00–40.00)−1.0820.279
 Lactate, mmol/L1.80 (1.60–2.15)1.95 (1.38–3.50)−0.5870.557
 C-reactive protein, mg/L114.74 (56.99–168.49)109.99 (58.96–178.84)−0.0030.998
 Procalcitonin, ng/mL1.78 (1.06–4.83)3.21 (0.98–12.50)b −3.746
 IL-1β, pg/mL1.51 (1.14–2.19)1.67 (0.77–3.07)3.07 (1.64–7.30),a 23.999
 IL-23, pg/mL2.67 (2.32–3.59)3.88 (3.07–5.75)a 7.47 (3.94–16.60),a 54.455
1.00 (1.00–2.00)7.50 (4.00–10.25)b −8.903
11.00 (8.00–19.50)15.00 (8.00–25.50)−1.6980.090
0 (0%)31 (41.90%)b 25.492
‘–’ – data not applicable; ICU – Intensive Care Unit; SBP – systolic blood pressure; DBP – diastolic blood pressure; IL-1β – interleukin 1 beta; IL-23 – interleukin 23; SOFA – sequential organ failure assessment.
a Differences were considered statistically significant with
b Differences were considered statistically significant with

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750