21 May 2023: Clinical Research
Value of IL-1β and IL-23 in Predicting 28-Day Mortality Due to Sepsis: A Retrospective Study
Jing Cao ABE* , Wenguang Liu CDE , Yong Li ABF , Bin Chen CDE , Tingfeng Yu DEF , Zhengbing He BCD , Yanke Hong EFDOI: 10.12659/MSM.940163
Med Sci Monit 2023; 29:e940163
Table 2 Comparison of general data and laboratory indicators of patients with different prognosis.
| Survivors (n=43) | Non-survivors (n=31) | Z/χ2 | P value | |
|---|---|---|---|---|
| Age, years [median (IQR)] | 53.0 (43.0–70.0) | 56.0 (44.0–66.0) | −0.247 | 0.805 |
| Male sex (n,%) | 33 (76.74%) | 22 (70.97%) | 0.315 | 0.575 |
| Urinary stones | 12 (27.91%) | 9 (29.03%) | 0.011 | 0.916 |
| Cerebral vascular disease | 11 (25.58%) | 7 (22.58%) | 0.088 | 0.767 |
| Diabetes mellitus | 3 (6.98%) | 6 (19.35%) | 1.555 | 0.212 |
| Hypertension | 15 (34.88%) | 10 (32.26%) | 0.056 | 0.814 |
| Hypoproteinemia | 7 (16.28%) | 11 (35.48%) | 3.609 | 0.057 |
| Temperature, °C | 36.50 (36.40–36.70) | 36.50 (36.20–36.60) | −1.839 | 0.066 |
| Breath rate, beats/min | 20.00 (20.00–21.00) | 21.00 (20.00–21.00) | −1.222 | 0.222 |
| Heart rate, beats/min | 88.00 (70.00–100.00) | 81.00 (76.00–99.00) | −0.559 | 0.576 |
| SBP, mmHg | 113.00 (100.00–123.00) | 109.00 (93.00–118.00) | −1.184 | 0.237 |
| DBP, mmHg | 70.00 (64.00–79.00) | 68.00 (62.00–84.00) | −0.411 | 0.681 |
| White blood cells, ×10/L | 12.49 (7.27–17.87) | 11.78 (10.31–16.49) | −0.274 | 0.784 |
| Neutrophils, ×10/L | 10.46 (6.48–15.14) | 10.44 (8.49–12.96) | −0.405 | 0.685 |
| Lymphocytes, ×10/L | 0.80 (0.46–1.08) | 0.69 (0.51–1.23) | −0.208 | 0.835 |
| Monocytes, ×10/L | 0.58 (0.31–0.85) | 0.55 (0.26–0.94) | −0.033 | 0.974 |
| Hematocrit, % | 34.60 (30.40–40.70) | 36.50 (25.80–44.70) | −0.137 | 0.891 |
| Platelets, ×10/L | 156.00 (127.00–202.00) | 175.00 (130.00–228.00) | −0.860 | 0.390 |
| Creatinine, μmol/L | 85.00 (57.00–182.00) | 103.00 (86.00–172.00) | −1.134 | 0.257 |
| Blood urea nitrogen, mmol/L | 7.75 (4.90–12.78) | 10.77 (7.26–19.52) | −1.846 | 0.065 |
| Uric acid, μmol/L | 269.00 (139.90–468.00) | 270.00 (130.00–440.00) | −0.186 | 0.852 |
| Total bilirubin, μmol/L | 18.90 (12.70–31.50) | 21.60 (15.90–43.00) | −0.920 | 0.357 |
| Partial pressure of oxygen, mmHg | 92.00 (65.00–112.00) | 80.00 (54.00–96.00) | −1.644 | 0.100 |
| Partial pressure of carbon dioxide, mmHg | 36.00 (32.00–40.00) | 35.00 (31.00–42.00) | −0.225 | 0.822 |
| Lactate, mmol/L | 1.60 (1.20–2.90) | 2.40 (1.50–3.60) | −1.650 | 0.099 |
| C-reactive protein, mg/L | 114.74 (56.99–168.49) | 123.75 (72.14–186.19) | −0.970 | 0.337 |
| Procalcitonin, ng/mL | 4.48 (1.48–8.43) | 6.23 (3.93–74.21) | −2.449 | 0.014 |
| IL-1β, pg/mL | 2.71 (1.32–5.04) | 5.26 (2.17–17.73) | −2.285 | 0.022 |
| IL-23, pg/mL | 4.35 (3.65–10.21) | 12.45 (7.33–28.73) | −3.879 | |
| 6.00 (3.00–9.00) | 9.00 (7.00–13.00) | −4.160 | ||
| 17.00 (10.00–23.00) | 13.00 (7.00–27.00) | −1.031 | 0.303 | |
| ICU – Intensive Care Unit; SBP – systolic blood pressure; DBP – diastolic blood pressure; IL-1β – interleukin 1 beta; IL-23 – interleukin 23; SOFA – sequential organ failure assessment. | ||||