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Current Volume 16(1) 2010 (26)

#878321

21 Dec 2009   

Barrier functionality and transport machineries of human ECV304 cells

Jaleh Barar, Mark Gumbleton [...]

Med Sci Monit 2010; 16(1): BR52-60 :: ID: 878321

#878321

21 Dec 2009   

Barrier functionality and transport machineries of human ECV304 cells

Jaleh Barar, Mark Gumbleton, Masoud Asadi, Yadollah Omidi

Med Sci Monit 2010; 16(1): BR52-60 :: ID: 878321

895

#878320

21 Dec 2009   

Synergistic action of doxorubicin and sulindac in human cervix carcinoma cells - studies on possible mechanisms

Beata Maria Gruber, Irena Bubko [...]

Med Sci Monit 2010; 16(1): BR45-51 :: ID: 878320

#878320

21 Dec 2009   

Synergistic action of doxorubicin and sulindac in human cervix carcinoma cells - studies on possible mechanisms

Beata Maria Gruber, Irena Bubko, Jolanta Krzyszton-Russjan, Elzbieta Lidia Anuszewska

Med Sci Monit 2010; 16(1): BR45-51 :: ID: 878320

871

#878319

21 Dec 2009   

Effect of levothyroxine replacement therapy on paraoxonase-1 and carotid intima-media thickness in subclinical hypothyroidism

Levent Kebapcilar, Abdurrahman Comlekci [...]

Med Sci Monit 2010; 16(1): CR41-47 :: ID: 878319

#878319

21 Dec 2009   

Effect of levothyroxine replacement therapy on paraoxonase-1 and carotid intima-media thickness in subclinical hypothyroidism

Levent Kebapcilar, Abdurrahman Comlekci, Pinar Tuncel, Ahmet Solak, Mustafa Secil, Omur Gencel, Mustafa Sahin, Ismail Sari, Sena Yesil

Med Sci Monit 2010; 16(1): CR41-47 :: ID: 878319

995

#878318

21 Dec 2009   

Comparison of thin-strut cobalt-chromium stents and stainless steel stents in a porcine model of neointimal hyperplasia

Krzysztof Milewski, Aleksander Zurakowski [...]

Med Sci Monit 2010; 16(1): BR40-44 :: ID: 878318

#878318

21 Dec 2009   

Comparison of thin-strut cobalt-chromium stents and stainless steel stents in a porcine model of neointimal hyperplasia

Krzysztof Milewski, Aleksander Zurakowski, Jacek Pajak, Ewa Pajak-Zielinska, Lukasz Liszka, Piotr P Buszman, Jaroslaw Bis, Marcin Debinski, Pawel E Buszman

Med Sci Monit 2010; 16(1): BR40-44 :: ID: 878318

1,022

#878317

21 Dec 2009   

Short term health impact of a yoga and diet change program on obesity

Shirley Telles, Visweswaraiah K Naveen [...]

Med Sci Monit 2010; 16(1): CR35-40 :: ID: 878317

#878317

21 Dec 2009   

Short term health impact of a yoga and diet change program on obesity

Shirley Telles, Visweswaraiah K Naveen, Acharya Balkrishna, Sanjay Kumar

Med Sci Monit 2010; 16(1): CR35-40 :: ID: 878317

2,424

#878316

21 Dec 2009   

Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet

Gabriella F Kocsis, Tamas Csont [...]

Med Sci Monit 2010; 16(1): BR32-39 :: ID: 878316

#878316

21 Dec 2009   

Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet

Gabriella F Kocsis, Tamas Csont, Zoltan Varga-Orvos, Laszlo G Puskas, Zsolt Murlasits, Peter Ferdinandy

Med Sci Monit 2010; 16(1): BR32-39 :: ID: 878316

1,133

#878315

21 Dec 2009   

Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome

Marlena Broncel, Marzena Kozirog [...]

Med Sci Monit 2010; 16(1): CR28-34 :: ID: 878315

#878315

21 Dec 2009   

Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome

Marlena Broncel, Marzena Kozirog, Piotr Duchnowicz, Maria Koter-Michalak, Joanna Sikora, Julita Chojnowska-Jezierska

Med Sci Monit 2010; 16(1): CR28-34 :: ID: 878315

2,218

#878314

21 Dec 2009   

Histological comparison of autograft, allograft-DBM, xenograft, and synthetic grafts in a trabecular bone defect: an experimental study in rabbits

Vasilis T Athanasiou, Dionysios J Papachristou [...]

Med Sci Monit 2010; 16(1): BR24-31 :: ID: 878314

#878314

21 Dec 2009   

Histological comparison of autograft, allograft-DBM, xenograft, and synthetic grafts in a trabecular bone defect: an experimental study in rabbits

Vasilis T Athanasiou, Dionysios J Papachristou, Andreas Panagopoulos, Alkis Saridis, Chrisoula D Scopa, Panagiotis Megas

Med Sci Monit 2010; 16(1): BR24-31 :: ID: 878314

1,567

#878313

21 Dec 2009   

The reliability of ELISA in predicting H. pylori infection in dyspeptic populations under age 45

Malgorzata Palka, Tomasz Tomasik [...]

Med Sci Monit 2010; 16(1): PH24-28 :: ID: 878313

#878313

21 Dec 2009   

The reliability of ELISA in predicting H. pylori infection in dyspeptic populations under age 45

Malgorzata Palka, Tomasz Tomasik, Adam Windak, Grzegorz Margas, Tomasz Mach, Agnieszka Bohonos

Med Sci Monit 2010; 16(1): PH24-28 :: ID: 878313

867

#878312

21 Dec 2009   

Threshold estimation in adult normal- and impaired-hearing subjects using auditory steady-state responses

Stavros Hatzopoulos, Silvano Prosser [...]

Med Sci Monit 2010; 16(1): CR21-27 :: ID: 878312

#878312

21 Dec 2009   

Threshold estimation in adult normal- and impaired-hearing subjects using auditory steady-state responses

Stavros Hatzopoulos, Silvano Prosser, Andrea Ciorba, Nadia Giarbini, Krzysztof Kochanek, Lech Sliwa, Henryk Skarzynski, Alessandro Martini

Med Sci Monit 2010; 16(1): CR21-27 :: ID: 878312

826

#878311

21 Dec 2009   

Complement 5b-9 complex-induced alterations in human RPE cell physiology

Wenbo Li, Song Chen [...]

Med Sci Monit 2010; 16(1): BR17-23 :: ID: 878311

#878311

21 Dec 2009   

Complement 5b-9 complex-induced alterations in human RPE cell physiology

Wenbo Li, Song Chen, Minwang Ma, Jiangyuan Qian, Xiubin Ma

Med Sci Monit 2010; 16(1): BR17-23 :: ID: 878311

932

#878310

21 Dec 2009   

Characteristics and prognosis of coronary revascularization procedure in patients age 80 and older presenting with acute myocardial infarction

Nicolas Mansencal, Remy Pilliere [...]

Med Sci Monit 2010; 16(1): CR15-20 :: ID: 878310

#878310

21 Dec 2009   

Characteristics and prognosis of coronary revascularization procedure in patients age 80 and older presenting with acute myocardial infarction

Nicolas Mansencal, Remy Pilliere, Roland N’Guetta, Alain Beauchet, Pascal Lacombe, Olivier Dubourg

Med Sci Monit 2010; 16(1): CR15-20 :: ID: 878310

905

#878309

21 Dec 2009   

Social reintegration of TBI patients: a solution to provide long-term support

Leszek Bulinski,

Med Sci Monit 2010; 16(1): PH14-23 :: ID: 878309

#878309

21 Dec 2009   

Social reintegration of TBI patients: a solution to provide long-term support

Leszek Bulinski

Med Sci Monit 2010; 16(1): PH14-23 :: ID: 878309

861

#878308

21 Dec 2009   

Effect of carbogen on tumour oxygenation and 32P-colloid interstitial irradiation response

Hong Wei Zhan, Hong Biao Liu [...]

Med Sci Monit 2010; 16(1): BR11-16 :: ID: 878308

#878308

21 Dec 2009   

Effect of carbogen on tumour oxygenation and 32P-colloid interstitial irradiation response

Hong Wei Zhan, Hong Biao Liu, Cheng Kan Bao, Xiao Juan Ye, Hong Zhang, Gang Qiang He

Med Sci Monit 2010; 16(1): BR11-16 :: ID: 878308

927

#878307

21 Dec 2009   

Antioxidant therapy in human endocrine disorders

Saeid Golbidi, Ismail Laher

Med Sci Monit 2010; 16(1): RA9-24 :: ID: 878307

#878307

21 Dec 2009   

Antioxidant therapy in human endocrine disorders

Saeid Golbidi, Ismail Laher

Med Sci Monit 2010; 16(1): RA9-24 :: ID: 878307

1,101

#878306

21 Dec 2009   

Effects of mild-stream bathing on recovery from mental fatigue

Kei Mizuno, Masaaki Tanaka [...]

Med Sci Monit 2010; 16(1): CR8-14 :: ID: 878306

#878306

21 Dec 2009   

Effects of mild-stream bathing on recovery from mental fatigue

Kei Mizuno, Masaaki Tanaka, Kanako Tajima, Naoki Okada, Kazumasa Rokushima, Yasuyoshi Watanabe

Med Sci Monit 2010; 16(1): CR8-14 :: ID: 878306

1,359

#878305

21 Dec 2009   

Psychosexual biography and the strategies used by women afflicted with stress urinary incontinence during intercourse: two case studies

Mariola Bidzan, Jerzy Smutek [...]

Med Sci Monit 2010; 16(1): CS6-10 :: ID: 878305

#878305

21 Dec 2009   

Psychosexual biography and the strategies used by women afflicted with stress urinary incontinence during intercourse: two case studies

Mariola Bidzan, Jerzy Smutek, Leszek Bidzan

Med Sci Monit 2010; 16(1): CS6-10 :: ID: 878305

924

#878304

21 Dec 2009   

Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: organ-specific effects independent of antihypertensive effects

Maria do Carmo Fernandez Vailati, Noeme Souza Rocha [...]

Med Sci Monit 2010; 16(1): BR6-10 :: ID: 878304

#878304

21 Dec 2009   

Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: organ-specific effects independent of antihypertensive effects

Maria do Carmo Fernandez Vailati, Noeme Souza Rocha, Luiz Shiguero Matsubara, Carlos Roberto Padovani, Denise Saretta Schwartz, Beatriz Bojikian Matsubara

Med Sci Monit 2010; 16(1): BR6-10 :: ID: 878304

882

#878296

21 Dec 2009   

Challenges in economic evaluation of new drugs: experience with rituximab in Hungary

Valentin Brodszky, Ewa Orlewska [...]

Med Sci Monit 2010; 16(1): SR1-5 :: ID: 878296

#878296

21 Dec 2009   

Challenges in economic evaluation of new drugs: experience with rituximab in Hungary

Valentin Brodszky, Ewa Orlewska, Martha Pentek, Krisztian Karpati, Jana Skoupa, Laszlo Gulacsi

Med Sci Monit 2010; 16(1): SR1-5 :: ID: 878296

962

#878303

21 Dec 2009   

Arterial baroreceptors in the management of systemic hypertension

Panagiotis Kougias, Sarah M Weakley [...]

Med Sci Monit 2010; 16(1): RA1-8 :: ID: 878303

#878303

21 Dec 2009   

Arterial baroreceptors in the management of systemic hypertension

Panagiotis Kougias, Sarah M Weakley, Qizhi Yao, Peter H Lin, Changyi Chen

Med Sci Monit 2010; 16(1): RA1-8 :: ID: 878303

1,211

#878302

21 Dec 2009   

Cerebral atherosclerosis causes neurodegenerative diseases

Hernando Rafael,

Med Sci Monit 2010; 16(1): LET1-2 :: ID: 878302

#878302

21 Dec 2009   

Cerebral atherosclerosis causes neurodegenerative diseases

Hernando Rafael

Med Sci Monit 2010; 16(1): LET1-2 :: ID: 878302

1,189

#878301

21 Dec 2009   

Federal funding for needle exchange programs

Peter A Clark, Matthew Fadus

Med Sci Monit 2010; 16(1): PH1-13 :: ID: 878301

#878301

21 Dec 2009   

Federal funding for needle exchange programs

Peter A Clark, Matthew Fadus

Med Sci Monit 2010; 16(1): PH1-13 :: ID: 878301

812

#878300

21 Dec 2009   

Effects of blue-green algae extracts on the proliferation of human adult stem cells in vitro: a preliminary study

Douglas R Shytle, Jun Tan [...]

Med Sci Monit 2010; 16(1): BR1-5 :: ID: 878300

#878300

21 Dec 2009   

Effects of blue-green algae extracts on the proliferation of human adult stem cells in vitro: a preliminary study

Douglas R Shytle, Jun Tan, Jared Ehrhart, Adam J Smith, Cyndy D Sanberg, Paul R Sanberg, Jerry Anderson, Paula C Bickford

Med Sci Monit 2010; 16(1): BR1-5 :: ID: 878300

1,326

#878299

21 Dec 2009   

Statins and beta-cell function

Lei Qian, Lihong Xu [...]

Med Sci Monit 2010; 16(1): HY1-2 :: ID: 878299

#878299

21 Dec 2009   

Statins and beta-cell function

Lei Qian, Lihong Xu, Yi Lin, Yongde Peng

Med Sci Monit 2010; 16(1): HY1-2 :: ID: 878299

929

#878298

21 Dec 2009   

Smoking and other personal characteristics as potential predictors for fecal bacteria populations in humans

Ikuko Kato, Jordan M Nechvatal [...]

Med Sci Monit 2010; 16(1): CR1-7 :: ID: 878298

#878298

21 Dec 2009   

Smoking and other personal characteristics as potential predictors for fecal bacteria populations in humans

Ikuko Kato, Jordan M Nechvatal, Sijana Dzinic, Marc D Basson, Adhip P Majumdar, Jeffrey L Ram

Med Sci Monit 2010; 16(1): CR1-7 :: ID: 878298

851

Volume 16(1) 2010 (26) Supplement

#880588

20 May 2010 :   

Lateral rectus muscle as a new reference point in estimation of Graves’ ophthalmopathy activity

Agata Majos, Michał Pająk [...]

Med Sci Monit 2010; 16(1): 80-85 :: ID: 880588

1,791 2

#880588

20 May 2010 :   

Lateral rectus muscle as a new reference point in estimation of Graves’ ophthalmopathy activity

Agata Majos, Michał Pająk, Marcin Elgalal, Marek Olszycki, Ludomir Stefańczyk

Med Sci Monit 2010; 16(1): 80-85 :: ID: 880588

1,791 2

#880587

20 May 2010 :   

Patient specific implants, designed using Rapid Prototyping and diagnostic imaging, for the repair of orbital fractures

Marcin T. Elgalal, Marcin Kozakiewicz [...]

Med Sci Monit 2010; 16(1): 75-79 :: ID: 880587

1,628 2

#880587

20 May 2010 :   

Patient specific implants, designed using Rapid Prototyping and diagnostic imaging, for the repair of orbital fractures

Marcin T. Elgalal, Marcin Kozakiewicz, Piotr Loba, Bogdan Walkowiak, Marek Olszycki, Ludomir Stefańczyk

Med Sci Monit 2010; 16(1): 75-79 :: ID: 880587

1,628 2

#880586

20 May 2010 :   

Comparison of efficacy of MR sequences used for detection of focal liver lesions

Andrzej Cieszanowski, Agnieszka Grodzicka [...]

Med Sci Monit 2010; 16(1): 66-74 :: ID: 880586

1,670 3

#880586

20 May 2010 :   

Comparison of efficacy of MR sequences used for detection of focal liver lesions

Andrzej Cieszanowski, Agnieszka Grodzicka, Edyta Maj, Barbara Gornicka, Kaczynski Bartosz, Mariusz Grodzicki, Marek Krawczyk, Olgierd Rowinski

Med Sci Monit 2010; 16(1): 66-74 :: ID: 880586

1,670 3

#880585

20 May 2010 :   

Brain MRI findings in preterm babies versus transfontanel sonography-own experience

Monika Bekiesinska-Figatowska, Ewa Helwich [...]

Med Sci Monit 2010; 16(1): 60-65 :: ID: 880585

1,618 2

#880585

20 May 2010 :   

Brain MRI findings in preterm babies versus transfontanel sonography-own experience

Monika Bekiesinska-Figatowska, Ewa Helwich, Hanna Bragoszewska, Anna Romaniuk-Doroszewska, Magdalena Rutkowska, Sylwia Szkudlinska-Pawlak, Ewa Adamska, Malgorzata Dzwonkowska

Med Sci Monit 2010; 16(1): 60-65 :: ID: 880585

1,618 2

#880584

20 May 2010 :   

The imaging features of selected congenital tumors – own material and literature review

Marek Duczkowski, Agnieszka Duczkowska [...]

Med Sci Monit 2010; 16(1): 52-59 :: ID: 880584

1,633 0

#880584

20 May 2010 :   

The imaging features of selected congenital tumors – own material and literature review

Marek Duczkowski, Agnieszka Duczkowska, Monika Bekiesinska-Figatowska, Hanna Bragoszewska, Maria Uliasz, Elzbieta Jurkiewicz

Med Sci Monit 2010; 16(1): 52-59 :: ID: 880584

1,633 0

#880583

20 May 2010 :   

Optimization of CT protocol for imaging of polytraumatized patients

Marcin Błaż, Piotr Palczewski [...]

Med Sci Monit 2010; 16(1): 48-51 :: ID: 880583

1,666 7

#880583

20 May 2010 :   

Optimization of CT protocol for imaging of polytraumatized patients

Marcin Błaż, Piotr Palczewski, Marek Gołębiowski, Wojciech Szeszkowski

Med Sci Monit 2010; 16(1): 48-51 :: ID: 880583

1,666 7

#880582

20 May 2010 :   

Iliac artery in-stent restenosis evaluation in 64-row CT

Wojciech Poncyljusz, Aleksander Falkowski [...]

Med Sci Monit 2010; 16(1): 43-47 :: ID: 880582

1,672 2

#880582

20 May 2010 :   

Iliac artery in-stent restenosis evaluation in 64-row CT

Wojciech Poncyljusz, Aleksander Falkowski, Marcin Sawicki, Monika Rać, Robert Juszkat

Med Sci Monit 2010; 16(1): 43-47 :: ID: 880582

1,672 2

#880581

20 May 2010 :   

Hydrogel-coated coils for the treatment of cerebral aneurysms

Wojciech Poncyljusz, Aleksander Falkowski [...]

Med Sci Monit 2010; 16(1): 40-42 :: ID: 880581

1,677 6

#880581

20 May 2010 :   

Hydrogel-coated coils for the treatment of cerebral aneurysms

Wojciech Poncyljusz, Aleksander Falkowski, Marcin Sawicki, Ireneusz Kojder, Robert Juszkat

Med Sci Monit 2010; 16(1): 40-42 :: ID: 880581

1,677 6

#880580

20 May 2010 :   

Technical aspects and short-term results of primary coiling of giant intracranial aneurysms: A 12-year, single-center experience

Zbigniew Serafin, Piotr Strześniewski [...]

Med Sci Monit 2010; 16(1): 33-39 :: ID: 880580

1,689 2

#880580

20 May 2010 :   

Technical aspects and short-term results of primary coiling of giant intracranial aneurysms: A 12-year, single-center experience

Zbigniew Serafin, Piotr Strześniewski, Maciej Osmański, Władysław Lasek, Wojciech Beuth

Med Sci Monit 2010; 16(1): 33-39 :: ID: 880580

1,689 2

#880579

20 May 2010 :   

Computed Tomographic Angiography in the diagnosis of brain death

Marcin Sawicki, Anna Walecka [...]

Med Sci Monit 2010; 16(1): 28-32 :: ID: 880579

1,596 0

#880579

20 May 2010 :   

Computed Tomographic Angiography in the diagnosis of brain death

Marcin Sawicki, Anna Walecka, Romuald Bohatyrewicz, Wojciech Poncyljusz, Janusz Kordowski

Med Sci Monit 2010; 16(1): 28-32 :: ID: 880579

1,596 0

#880578

20 May 2010 :   

Response of the hand’s small vessel to the cold immersion test, using a blood pool MRA contrast agent – the new perspective in evaluating vasospasm

Marek Olszycki, Agata Majos [...]

Med Sci Monit 2010; 16(1): 24-27 :: ID: 880578

1,828 0

#880578

20 May 2010 :   

Response of the hand’s small vessel to the cold immersion test, using a blood pool MRA contrast agent – the new perspective in evaluating vasospasm

Marek Olszycki, Agata Majos, Piotr Grzelak, Ludomir Stefańczyk

Med Sci Monit 2010; 16(1): 24-27 :: ID: 880578

1,828 0

#880577

20 May 2010 :   

Change of the brain proton magnetic resonance spectroscopy metabolite’s ratios with aging

Paweł Krukowski, Przemysław Podgórski [...]

Med Sci Monit 2010; 16(1): 19-23 :: ID: 880577

1,724 1

#880577

20 May 2010 :   

Change of the brain proton magnetic resonance spectroscopy metabolite’s ratios with aging

Paweł Krukowski, Przemysław Podgórski, Maciej Guziński, Paweł Szewczyk, Marek Sąsiadek

Med Sci Monit 2010; 16(1): 19-23 :: ID: 880577

1,724 1

#880576

20 May 2010 :   

1H-MRS in mild cognitive impairment (MCI) – the role of particular metabolites in prediction of MCI conversion to AD

Jerzy Walecki, Agnieszka Pawłowska [...]

Med Sci Monit 2010; 16(1): 11-18 :: ID: 880576

1,829 5

#880576

20 May 2010 :   

1H-MRS in mild cognitive impairment (MCI) – the role of particular metabolites in prediction of MCI conversion to AD

Jerzy Walecki, Agnieszka Pawłowska, Tomasz Gabryelewicz, Jarosław B. Ćwikła, Maria Barcikowska, Tomasz Nesteruk

Med Sci Monit 2010; 16(1): 11-18 :: ID: 880576

1,829 5

#880575

20 May 2010 :   

Usefulness of perfusion-weighted MR imaging in the differential diagnosis of Alzheimer’s disease and mild cognitive impairment

Anna Zimny, Paweł Szewczyk [...]

Med Sci Monit 2010; 16(1): 5-10 :: ID: 880575

1,659 0

#880575

20 May 2010 :   

Usefulness of perfusion-weighted MR imaging in the differential diagnosis of Alzheimer’s disease and mild cognitive impairment

Anna Zimny, Paweł Szewczyk, Anna Czarnecka, Elżbieta Trypka, Renata Wojtyńska, Jerzy Leszek, Marek Sąsiadek

Med Sci Monit 2010; 16(1): 5-10 :: ID: 880575

1,659 0

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

08 Feb 2024 : Database Analysis  

Comparative Accuracy of Intraoral and Extraoral Digital Workflows for Short Span Implant Supported Fixed Pa...

Med Sci Monit In Press; DOI: 10.12659/MSM.943706  

08 Feb 2024 : Clinical Research  

Serum Selenium Concentration as a Potential Diagnostic Marker for Early-Stage Colorectal Cancer: A Comparat...

Med Sci Monit In Press; DOI: 10.12659/MSM.942882  

09 Feb 2024 : Clinical Research  

Factors Influencing the Occurrence of Intraoperative Hypothermia in Patients Undergoing General Anesthesia ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943463  

13 Feb 2024 : Clinical Research  

A Retrospective Study to Compare the Glasgow Coma Score, Pediatric Trauma Score, and Injury Severity Score ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943501  

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17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750