09 December 2020: Clinical Research
Efficacy and Safety of Image-Guided Intensity-Modulated Radiation Therapy and Volumetric Modulated Arc Therapy Combined with Paclitaxel Liposomes and Cisplatin for Locally Advanced Stage IIB–IIIB Cervical Cancer: A Retrospective Study at a Single Center
Meihua Xie ABE* , Xiuxiu Ding BCE* , Aiyu Chen CF , Huiqin Xiao DF , Xiaoye Wang BD , Youhong Wang AC , Huan Zhang ADG*DOI: 10.12659/MSM.927563
Med Sci Monit 2020; 26:e927563
Table 4 Comparison of preoperative and postoperative serum inflammatory factors and tumor markers of patients in the two studied groups.
| IMRT group (n=63) | VMAT group (n=63) | P-value | |
|---|---|---|---|
| VEGF (pg/mL) | |||
| Preoperative | 202.23±70.84 | 206.48±73.78 | 0.742 |
| Postoperative | 86.14±19.09 | 78.62±16.14 | 0.019 |
| SCCA (mg/L) | |||
| Preoperative | 7.51±1.19 | 7.69±1.43 | 0.444 |
| Postoperative | 4.42±0.63 | 3.83±0.72 | 0.001 |
| IL-8 (pg/mL) | |||
| Preoperative | 0.24±0.18 | 0.21±0.17 | 0.338 |
| Postoperative | 0.14±0.09 | 0.10±0.07 | 0.006 |
| TNF-α (pg/mL) | |||
| Preoperative | 2.82±0.78 | 2.69±0.70 | 0.327 |
| Postoperative | 1.18±0.32 | 1.04±0.26 | 0.008 |
| CEA (μg/L) | |||
| Preoperative | 21.89±4.13 | 22.37±4.26 | 0.522 |
| Postoperative | 9.61±1.14 | 9.04±1.45 | 0.016 |
| CA125 (U/mL) | |||
| Preoperative | 45.27±5.63 | 44.72±5.60 | 0.584 |
| Postoperative | 24.47±4.51 | 22.68±4.38 | 0.026 |
| IMRT – intensity-modulated radiation therapy; VMAT – volumetric modulated arc therapy; VEGF – vascular endothelial growth factor; SCCA – squamous cell carcinoma antigen; IL – interleukin; TNF – tumor necrosis factor; CEA – carcino-embryonic antigen; CA – carbohydrate antigen. | |||