04 March 2021>: Database Analysis
Identification of Biomarkers Based on Bioinformatics Analysis: The Expression of Ubiquitin-Conjugating Enzyme E2T (UBE2T) in the Carcinogenesis and Progression of Hepatocellular Carcinoma
Xuemiao Zhao 1ABEF , Wei Weng 2ACDE , Miao Jin 3CD , Sunjian Li 4AB , Qingwei Chen 5EF , Bingrong Li 2BC , Zhou Zhou 6BC , Chuanqiang Lan 2BE , Yunjun Yang 1AEF*DOI: 10.12659/MSM.929023
Med Sci Monit 2021; 27:e929023
Table 1 GO and KEGG pathway enrichment analysis of DEGs in HCC samples.
Category | Term | Description | Count | FDR |
---|---|---|---|---|
GOTERM_BP_DIRECT | GO: 0019373 | Epoxygenase P450 pathway | 10 | 8.46E-10 |
GOTERM_BP_DIRECT | GO: 0055114 | Oxidation-reduction process | 30 | 1.60E-06 |
GOTERM_BP_DIRECT | GO: 0006956 | Complement activation | 11 | 5.79E-05 |
GOTERM_BP_DIRECT | GO: 0006805 | Xenobiotic metabolic process | 10 | 1.74E-04 |
GOTERM_BP_DIRECT | GO: 0071356 | Cellular response to tumor necrosis factor | 10 | 0.002280078 |
GOTERM_BP_DIRECT | GO: 0006508 | Proteolysis | 20 | 0.004661937 |
GOTERM_CC_DIRECT | GO: 0005576 | Extracellular region | 63 | 2.51E-13 |
GOTERM_CC_DIRECT | GO: 0031090 | Organelle membrane | 16 | 2.80E-11 |
GOTERM_CC_DIRECT | GO: 0070062 | Extracellular exosome | 79 | 3.65E-10 |
GOTERM_CC_DIRECT | GO: 0005615 | Extracellular space | 48 | 1.08E-08 |
GOTERM_CC_DIRECT | GO: 0072562 | Blood microparticle | 12 | 1.30E-04 |
GOTERM_MF_DIRECT | GO: 0020037 | Heme binding | 19 | 8.03E-11 |
GOTERM_MF_DIRECT | GO: 0016705 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 14 | 8.03E-11 |
GOTERM_MF_DIRECT | GO: 0004497 | Monooxygenase activity | 13 | 1.55E-09 |
GOTERM_MF_DIRECT | GO: 0005506 | Iron ion binding | 18 | 1.94E-09 |
GOTERM_MF_DIRECT | GO: 0019825 | Oxygen binding | 11 | 3.24E-08 |
GOTERM_MF_DIRECT | GO: 0004252 | Serine-type endopeptidase activity | 17 | 1.73E-05 |
GOTERM_MF_DIRECT | GO: 0003824 | Catalytic activity | 11 | 0.008200616 |
KEGG_PATHWAY | hsa01100 | Metabolic pathways | 58 | 5.92E-08 |
KEGG_PATHWAY | hsa04610 | Complement and coagulation cascades | 11 | 7.69E-05 |
KEGG_PATHWAY | hsa05204 | Chemical carcinogenesis | 11 | 2.30E-04 |
KEGG_PATHWAY | hsa01200 | Carbon metabolism | 12 | 7.12E-04 |
KEGG_PATHWAY | hsa01130 | Biosynthesis of antibiotics | 14 | 0.007712682 |
GOTERM_BP_DIRECT | GO: 0007067 | Mitotic nuclear division | 10 | 9.83E-06 |
GOTERM_BP_DIRECT | GO: 0051301 | Cell division | 11 | 9.83E-06 |
GOTERM_CC_DIRECT | GO: 0005654 | Nucleoplasm | 22 | 1.84E-04 |
GOTERM_CC_DIRECT | GO: 0005634 | Nucleus | 30 | 7.93E-04 |
GOTERM_CC_DIRECT | GO: 0005829 | Cytosol | 21 | 0.005534764 |
GO – Gene Ontology; KEGG – Kyoto Encyclopedia of Genes and Genomes; DEGs – differentially expressed genes; HCC – hepatocellular carcinoma; FDR – false discovery rate. |