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15 March 2021: Lab/In Vitro Research

Long Noncoding RNA TCONS_00068220 Promotes Breast Cancer Progression by Regulating Epithelial-Mesenchymal Transition Marker E-Cadherin

Xiao Liu 12ABEF , Xingsong Tian 1ACDG

DOI: 10.12659/MSM.929832

Med Sci Monit 2021; 27:e929832

Table 1 The correlation between TCONS_00068220 expression level and clinicopathological features of breast cancer patients.

CharacteristicsTCONS_00068220 levelP-value
High (n, %)Low (n, %)
Age (years)≥5019 (63.3)24 (80.0)0.153
11 (36.7)6 (20.0)
Her-2Negative21 (70.0)19 (63.3)0.239
Positive9 (30.0)11 (36.7)
TNBCTNBC18 (60.0)17 (56.7)0.135
Non-TNBC12 (40.0)13 (43.3)
Ki67High index25 (83.3)16 (53.3)0.042
Low index5 (16.7)14 (46.7)
Lymphatic metastasisNegative6 (20.0)19 (63.3)0.000
Positive24 (80.0)11 (36.7)
Differentiation statusWell/moderate7 (23.3)18 (60.0)0.012
Poor23 (76.7)12 (40.0)
TNM stageI–II20 (66.7)13 (43.3)0.014
III–IV10 (33.3)17 (56.7)
TNBC – triple-negative breast cancer; TNM – tumor, node, metastasis.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750