30 January 2022>: Database Analysis
Impact of Post-Mastectomy Radiation Therapy for Sentinel Lymph Node Micrometastases in Early-Stage Breast Cancer Patients
Hua Luo ACDEF** , Ou Ou Yang BCF* , Jun Ling He BCD , Tian Lan AD*DOI: 10.12659/MSM.933275
Med Sci Monit 2022; 28:e933275
Table 3 Univariate and multivariate analyses of overall survival in unmatched and matched cohort.
Characteristics | Before PSM | After PSM | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
5 year OS | Univariate | Multivariate | 5 year OS | Univariate | Multivariate | |||||||
Chisq | P | HR | 95%CI | P | Chisq | P | HR | 95%CI | P | |||
Age | 50.288 | 8.045 | 0.005 | |||||||||
0.954 | Reference | 0.944 | Reference | |||||||||
>50 | 0.879 | 2.03 | 1.48–2.78 | 0.918 | 1.39 | 0.87–2.22 | 0.168 | |||||
Marital status | 79.005 | 9.054 | 0.003 | |||||||||
Married | 0.938 | Reference | 0.942 | Reference | ||||||||
Unmarried | 0.84 | 2.22 | 1.78–2.77 | 0.896 | 1.48 | 0.98–2.22 | 0.061 | |||||
Race | 0.803 | 0.37 | 1.47 | 0.225 | ||||||||
Non White | 0.915 | Reference | 0.936 | Reference | ||||||||
White | 0.901 | 1.09 | 0.8–1.48 | 0.603 | 0.925 | 1.43 | 0.75–2.71 | 0.277 | ||||
Median household income | 8.782 | 0.032 | 12.242 | 0.007 | ||||||||
Quartile 1 | 0.861 | Reference | 0.862 | Reference | ||||||||
Quartile 2 | 0.919 | 0.87 | 0.7–1.07 | 0.197 | 0.931 | 0.64 | 0.44–0.94 | 0.022 | ||||
Quartile 3 | 0.91 | 1.15 | 0.92–1.43 | 0.212 | 0.953 | 1.39 | 0.92–2.08 | 0.115 | ||||
Quartile 4 | 0.92 | 0.86 | 0.68–1.08 | 0.188 | 0.954 | 0.86 | 0.55–1.34 | 0.503 | ||||
T stage | 25.135 | 15.59 | ||||||||||
T0/1 | 0.925 | Reference | 0.964 | Reference | ||||||||
T2 | 0.876 | 1.69 | 1.35–2.11 | 0.897 | 2.78 | 1.79–4.31 | ||||||
Grade | 17.861 | 7.583 | 0.006 | |||||||||
I+II | 0.917 | Reference | 0.94 | Reference | ||||||||
III | 0.867 | 1.44 | 1.12–1.84 | 0.005 | 0.899 | 1.37 | 0.87–2.16 | 0.169 | ||||
ER status | 25.656 | 21.061 | ||||||||||
Negative | 0.788 | Reference | 0.785 | Reference | ||||||||
Positive | 0.919 | 0.77 | 0.54–1.09 | 0.141 | 0.946 | 0.44 | 0.22–0.87 | 0.018 | ||||
PR status | 45.864 | 16.306 | ||||||||||
Negative | 0.814 | Reference | 0.858 | Reference | ||||||||
Positive | 0.928 | 0.60 | 0.44–0.8 | 0.001 | 0.947 | 0.66 | 0.37–1.17 | 0.154 | ||||
Radiation | 0.531 | 0.466 | 1.056 | 0.304 | ||||||||
None/unknown | 0.901 | Reference | 0.939 | Reference | ||||||||
Yes | 0.912 | 1.07 | 0.78–1.45 | 0.686 | 0.912 | 1.27 | 0.85–1.89 | 0.243 | ||||
Chemotherapy | 31.872 | 13.02 | ||||||||||
No/unknown | 0.877 | Reference | 0.914 | Reference | ||||||||
Yes | 0.929 | 0.55 | 0.43–0.7 | 0.933 | 0.41 | 0.26–0.62 | ||||||
OS – overall survivall; PSM – propensity score matching; HR – hazard ratio; CI – confidence interval. |