04 November 2021>: Lab/In Vitro Research
Association of Single-Nucleotide Polymorphisms of Gab1 Gene with Susceptibility to Meningioma in a Northern Chinese Han Population
Weifeng Chen 12ABCEF* , Jiahui Zhao 3ABC* , Qianlan Wu 4BC* , Hongshan Yan 1DF , Xiaoyan Wang 1CD , Chengrui Nan 1CD , Zhen Wu 5FG , Lei Chen 6FG , Zongmao Zhao 1AEG*DOI: 10.12659/MSM.933444
Med Sci Monit 2021; 27:e933444
Table 3 Stratification analysis between Gab1 single-nucleotide polymorphisms and the clinical characteristics of meningioma.
Clinical characteristics (n) | rs3805246 | rs3828512 | rs3805236 | rs1397529 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
GG | AG+GG | P | AA | AG+GG | P | AA | AG+GG | P | AA | AC | P | |
Tumor size (cm) | ||||||||||||
d ≤4.5 (109) | 66 | 43 | 0.552 | 62 | 47 | 0.413 | 56 | 53 | 0.690 | 87 | 22 | 0.409 |
d >4.5 (96) | 62 | 34 | 60 | 36 | 52 | 44 | 72 | 24 | ||||
Location | ||||||||||||
Convexity (87) | 51 | 36 | 1.559 | 48 | 39 | 2.807 | 41 | 46 | 1.894 | 63 | 24 | 2.385 |
Skull basis (66) | 41 | 25 | 38 | 28 | 37 | 29 | 54 | 12 | ||||
Others (52) | 36 | 16 | 35 | 17 | 29 | 23 | 42 | 9 | ||||
WHO grade | ||||||||||||
I (150) | 97 | 53 | 0.277 | 92 | 58 | 0.380 | 79 | 71 | 0.994 | 115 | 35 | 0.612 |
II+III (55) | 31 | 24 | 30 | 25 | 29 | 26 | 44 | 11 | ||||
Peritumoral edema | ||||||||||||
Yes (120) | 80 | 40 | 0.138 | 76 | 44 | 0.185 | 63 | 57 | 0.950 | 91 | 29 | 0.481 |
No (85) | 48 | 37 | 46 | 39 | 45 | 40 | 68 | 17 | ||||
Dural invasion | ||||||||||||
Yes (91) | 59 | 32 | 0.527 | 56 | 35 | 0.597 | 49 | 42 | 0.766 | 64 | 27 | 0.027 |
No (114) | 69 | 45 | 66 | 48 | 59 | 55 | 95 | 19 |