03 March 2022: Clinical Research
Alteration of Serum Metabolites in Women of Reproductive Age with Chronic Constipation
Shuai Liu ABCEF* , Chuanli Yang ACD* , Hongxia Li BF , Xinshu Bai B , Tianjiao Hu B , Xin Xue B , Jie An F , Yan Zhang F , Xiushan Dong AG*DOI: 10.12659/MSM.934117
Med Sci Monit 2022; 28:e934117
Table 2 Differences in upregulated metabolites between patients with constipation and healthy controls.
| MS2 name | C | N | VIP | P |
|---|---|---|---|---|
| 1,2-Benzenedicarboxylic acid | 1.981 | 0.870 | 2.093 | 0.010 |
| 1,7-Dimethylxanthine | 1.661 | 0.887 | 1.961 | 0.021 |
| 2-Hydroxyphenylacetic acid | 2.234 | 0.968 | 1.126 | 0.010 |
| 3b-Hydroxy-5-cholenoic acid | 2.229 | 1.249 | 2.133 | 0.014 |
| 3-Indoleacetonitrile | 1.626 | 1.470 | 2.445 | 0.032 |
| 5-Hydroxy-L-lysine | 1.054 | 0.856 | 1.815 | 0.017 |
| Cyanuric acid | 1.096 | 0.893 | 1.779 | 0.042 |
| Erythrono-1,4-lactone | 1.112 | 0.919 | 1.478 | 0.044 |
| Flavin mononucleotide (FMN) | 1.254 | 0.822 | 2.341 | 0.016 |
| Gly-Val | 1.000 | 0.849 | 1.358 | 0.029 |
| Hesperetin | 1.078 | 0.749 | 2.273 | 0.015 |
| Hippuric acid | 1.254 | 0.581 | 2.697 | 0.007 |
| Ile-Ala | 0.807 | 0.593 | 1.925 | 0.011 |
| Ile-Pro | 1.050 | 0.880 | 1.307 | 0.049 |
| L-Gulonic gamma-lactone | 1.185 | 0.945 | 2.542 | 0.009 |
| L-Pipecolic acid | 1.158 | 0.927 | 1.238 | 0.025 |
| Propylene glycol | 0.929 | 0.526 | 1.606 | 0.039 |
| Pyrrolidine | 1.182 | 0.804 | 2.553 | 0.005 |
| Saccharin | 1.175 | 0.796 | 1.613 | 0.037 |
| Sinigrin | 0.817 | 0.664 | 1.850 | 0.015 |