Alteration of Serum Metabolites in Women of Reproductive Age with Chronic Constipation

03 March 2022: Clinical Research

Shuai Liu ^ABCEF* , Chuanli Yang ^ACD* , Hongxia Li ^BF , Xinshu Bai ^B , Tianjiao Hu ^B , Xin Xue ^B , Jie An ^F , Yan Zhang ^F , Xiushan Dong ^AG*

DOI: 10.12659/MSM.934117

Med Sci Monit 2022; 28:e934117

Table 3 Differences in downregulated metabolites between patients with constipation and healthy controls.

MS2 name	C	N	VIP	P
.gamma.-L-Glu-.epsilon.-L-Lys	0.747	0.980	1.451	0.047
11-Keto-.beta.-boswellic acid	0.646	0.811	1.568	0.049
12-Oxo-2,3-dinor-10,15-phytodienoic acid	0.950	1.229	2.643	0.026
1-Aminocyclopropanecarboxylic acid	1.035	1.181	2.341	0.007
20-HETE	2.350	3.920	2.913	0.001
3-Mercaptopyruvic acid	1.092	2.194	1.211	0.041
5,6,7,8-tetrahydro-2-Naphthoic Acid	0.882	1.356	2.192	0.029
5-Methyl-5,6-Dihydrouracil	1.184	1.386	1.821	0.029
Adenine	0.985	1.132	1.841	0.041
Ala-Lys	0.763	1.230	2.044	0.049
alpha-Guanidinoglutaric Acid	1.130	1.570	2.627	0.009
Benzylbutylphthalate	0.688	0.955	2.116	0.046
D-Alanyl-D-alanine (D-Ala-D-Ala)	0.796	1.241	2.088	0.031
Desipramine	1.018	1.181	1.662	0.039
DL-Phenylalanine	0.647	1.064	2.231	0.014
Glycine	0.955	1.284	2.392	0.007
Gly-Ser	1.323	1.465	1.929	0.019
Jasmine lactone	1.534	1.934	1.891	0.018
Lanosterol	1.187	1.415	2.059	0.030
Larixinic Acid	0.783	1.083	1.893	0.021
L-leucyl-L-proline	1.449	3.674	1.502	0.028
L-Pyroglutamic acid	1.366	2.002	1.990	0.023
L-Valine	0.814	1.162	1.839	0.033
Met-Ala	1.016	1.768	2.181	0.030
N-Acetyl-L-glutamic acid	1.117	1.677	1.940	0.028
N-Formylmethionine	1.496	2.408	1.927	0.023
Phosphorylcholine	0.963	1.132	1.758	0.029
Primidone	0.890	1.701	3.274	0.000
Tripelennamine	0.757	1.403	3.252	0.005
Tyr-Ala	0.636	1.314	2.296	0.018