13 February 2022>: Clinical Research
Gas Chromatography and Flame-Ionization Detection of Non-Cholesterol Sterols as Indicators of Cholesterol Absorption and Synthesis in 158 Chinese Individuals with Normolipidemia, Hyperlipidemia, and Familial Hypercholesterolemia
Zhi-Zhao Li 1DE* , Qi-Hui Wang 2C , Yang Liu 2C , Lv-Ya Wang 3A , Zhen-Qiu Yu 3A , Qiong Huang 4B , Jing Zhang 5BDOI: 10.12659/MSM.934471
Med Sci Monit 2022; 28:e934471
Table 2 Concentration and ratio of cholesterol synthesis and absorption markers to cholesterol in healthy group and dyslipidemia and familial hypercholesterolemia groups.
Sterols | Concentration (mg/dL) | ||||
---|---|---|---|---|---|
Healthy group (n=64) | Dyslipidemia group (n=69) | FH group (n=25) | F | P | |
Squalene | 0.121 (0.099, 0.152) | 0.160 (0.113, 0.254) | 0.207 (0.119, 0.583) | 0.075 | 0.928 |
Desmosterol | 0.024±0.007 | 0.029±0.008 | 0.322±0.150 | 260.252 | |
Lathosterol | 0.207 (0.159, 0.256) | 0.322±0.126 | 0.653±0.416 | 46.503 | |
Campesterol | 0.212 (0.156, 0.317) | 0.210 (0.140, 0.345) | 0.647 (0.382, 1.142) | 31.747 | |
Stigmasterol | 0.049 (0.045, 0.055) | 0.051±0.011 | 0.153 (0.102, 0.230) | 27.224 | |
Sitosterol | 0.305 (0.220, 0.389) | 0.340 (0.239, 0.496) | 0.802 (0.553, 1.379) | 15.16 | |
Total | 0.995 (0.814, 1.171) | 1.212 (0.974, 1.482) | 2.826 (2.130, 5.187) | 28.439 | |
Squalene | 0.080 (0.066, 0.111) | 0.089 (0.059, 0.153) | 0.043±0.017 | 1.177 | 0.311 |
Desmosterol | 0.016 (0.014, 0.019) | 0.017±0.004 | 0.050 (0.035, 0.080) | 100.475 | |
Lathosterol | 0.154±0.034 | 0.191±0.075 | 0.099 (0.063, 0.127) | 14.625 | |
Campesterol | 0.148 (0.099, 0.240) | 0.118 (0.087, 0.193) | 0.105 (0.077, 0.163) | 1.202 | 0.303 |
Stigmasterol | 0.032 (0.028, 0.039) | 0.028±0.007 | 0.022 (0.017, 0.032) | 1.267 | 0.285 |
Sitosterol | 0.208 (0.148, 0.251) | 0.184 (0.155, 0.245) | 0.129 (0.094, 0.174) | 1.56 | 0.213 |
Total | 0.672 (0.549, 0.800) | 0.664 (0.575, 0.787) | 0.458 (0.382, 0.565) | 0.222 | 0.802 |