Circulating Cell-Free Mitochondrial DNA: A Potential Blood-Based Biomarker for Sarcopenia in Patients Undergoing Maintenance Hemodialysis

09 March 2022: Clinical Research

Zhen Fan ^1ABCEG* , Yi Guo ^2BCD* , Xiao-yi Zhong ^3CF*

DOI: 10.12659/MSM.934679

Med Sci Monit 2022; 28:e934679

Table 1 Characteristics and laboratory data of MHD patients with and without sarcopenia.

Variable	NSP (n=82)	SP (n=23)	t/χ2/Z	p
Age (years)	55.40±1.58	59.78±3.14	−1.282	0.203
Gender (M/F)	45/37	14/9	0.262	0.609
Dialysis duration (years)	4.56±0.32	6.32±0.82	−1.976	0.048
BMI (kg/m)	23.09±0.54	20.26±0.72	−2.553	0.011
HS (kg)	24.71±0.53	17.73±1.20	−4.733
SMI (kg/m)	7.93±0.20	5.07±0.26	−6.240
Cr (μmol/L)	900.32±53.17	876.37±61.06	−0.221	0.825
SBP (mmHg)	147.88±4.23	148.69±9.59	−0.391	0.696
DBP (mmHg)	90.57±2.72	83.70±5.55	1.161	0.248
TC (mmol/L)	3.78±0.17	4.07±0.39	−0.662	0.508
TG (mmol/L)	2.59±0.25	1.93±0.36	−1.364	0.173
LDL-C (mmol/L)	2.87±0.16	2.95±0.29	−0.046	0.963
FBS (mmol/L)	7.76±0.44	7.91±0.74	−0.666	0.505
Ab (g/L)	28.26±1.14	27.18±2.34	−0.504	0.615
Hb (g/L)	88.08±2.73	89.87±3.35	−0.328	0.744
VitD (ng/mL)	30.00±1.01	25.13±1.93	2.259	0.026
Ca (mmol/L)	2.03±0.04	1.96±0.08	−0.608	0.543
P (mmol/L)	1.88±0.11	1.42±0.17	−2.038	0.042
hs-CRP (mg/L)	6.73±0.58	7.56±1.28	−0.535	0.593
ccf-mtDNA (10 copies/uL)	3.72±0.27	6.19±0.77	−3.452
BMI – body mass index; HS – handgrip strength; SMI – skeletal muscle index; Cr – creatinine; SBP – systolic blood pressure; DBP – diastolic blood pressure; TC – total cholesterol; TG – triglyceride; LDL-C – low-density lipoprotein cholesterol; FBS – fasting blood sugar; Ab – albumin; Hb – hemoglobin; VitD – vitamin D; Ca – calcium; P – phosphorus; hs-CRP – high-sensitivity C-reactive protein; ccf-mtDNA – circulating cell-free mitochondrial DNA.