13 April 2022>: Clinical Research
External Quality Assessment of Maternal Serum Levels of Alpha-Fetoprotein, Free Beta-Human Chorionic Gonadotropin, and Unconjugated Estriol in Detecting Down Syndrome and Neural Tube Defects in the Second Trimester of 87 Maternal Serum Samples, Based on 105-139 Days
Yiming Chen 12AEG** , Yijie Chen 2BE* , Yezhen Shi 3CD , Wenwen Ning 2BE , Xiaoying Wang 1B , Liyao Li 1BC , Huimin Zhang 2FDOI: 10.12659/MSM.935573
Med Sci Monit 2022; 28:e935573
Table 1 Comparison of screening results in different screening laboratories.
Maternal markers | Lab A | Lab B | Lab C | Lab D | Lab E | Lab F | P value |
---|---|---|---|---|---|---|---|
AFP | 43.19 | 41.10 | 41.30 | 44.00 | 40.90 | 30.52 | |
(33.91, 63.04) | (32.00, 61.10) | (32.80, 60.20) | (34.30, 65.00) | (31.98, 58.64) | (22.96, 44.42) | ||
free β-hCG | 14.17 | 13.20 | 12.40 | 14.20 | 12.63 | 12.15 | 0.673 |
(8.24, 22.35) | (8.11, 20.50) | (7.42, 20.80) | (7.92, 23.20) | (7.63, 21.04) | (6.97, 21.56) | ||
uE3 | 5.22 | 4.99 | 5.75 | 5.30 | 5.07 | 4.98 | 0.633 |
(3.47, 6.65) | (3.49, 6.55) | (3.59, 7.47) | (3.53, 6.48) | (3.26, 7.02) | (3.29, 6.36) | ||
AFP MoM | 1.11 | 1.05 | 0.97 | 1.08 | 1.01 | 0.78 | |
(0.92, 1.47) | (0.85, 1.38) | (0.81, 1.25) | (0.88, 1.41) | (0.82, 1.35) | (0.61, 1.02) | ||
Free β-hCG MoM | 1.01 | 1.06 | 0.88 | 0.99 | 0.94 | 0.84 | 0.342 |
(0.67, 1.52) | (0.71, 1.56) | (0.59, 1.47) | (0.61, 1.58) | (0.61, 1.38) | (0.56, 1.33) | ||
uE3 MoM | 0.95 | 0.94 | 1.05 | 0.95 | 0.96 | 0.84 | 0.008 |
(0.75, 1.11) | (0.80, 1.08) | (0.81, 1.22) | (0.84, 1.11) | (0.75, 1.12) | (0.70, 1.08) | ||
Lab – laboratory; AFP – α-fetoprotein; free β-hCG – free beta human chorionic gonadotropin; uE3 – unconjugated estriol; MoM – multiple of median. |