13 April 2022: Clinical Research
External Quality Assessment of Maternal Serum Levels of Alpha-Fetoprotein, Free Beta-Human Chorionic Gonadotropin, and Unconjugated Estriol in Detecting Down Syndrome and Neural Tube Defects in the Second Trimester of 87 Maternal Serum Samples, Based on 105-139 Days
Yiming Chen 12AEG** , Yijie Chen 2BE* , Yezhen Shi 3CD , Wenwen Ning 2BE , Xiaoying Wang 1B , Liyao Li 1BC , Huimin Zhang 2FDOI: 10.12659/MSM.935573
Med Sci Monit 2022; 28:e935573
Table 4 Comparison of T21 screening effect in 6 different laboratories.
| Laboratory High/Low risk | T21 diagnostic result | Total | P value | Kappa value | ||
|---|---|---|---|---|---|---|
| Normal | T21 | |||||
| Lab A | Low risk | 75 | 1 | 76 | 0.625 | 0.575 |
| High risk | 3 | 3 | 6 | |||
| Lab B | Low risk | 77 | 1 | 78 | 1.000 | 0.737 |
| High risk | 1 | 3 | 4 | |||
| Lab C | Low risk | 77 | 1 | 78 | 1.000 | 0.737 |
| High risk | 1 | 3 | 4 | |||
| Lab D | Low risk | 77 | 1 | 78 | 1.000 | 0.737 |
| High risk | 1 | 3 | 4 | |||
| Lab E | Low risk | 77 | 1 | 78 | 1.000 | 0.737 |
| High risk | 1 | 3 | 4 | |||
| Lab F | Low risk | 74 | 1 | 75 | 0.375 | 0.515 |
| High risk | 4 | 3 | 7 | |||
| Lab – laboratory; T21 – trisomy 21. | ||||||