13 April 2022: Clinical Research
External Quality Assessment of Maternal Serum Levels of Alpha-Fetoprotein, Free Beta-Human Chorionic Gonadotropin, and Unconjugated Estriol in Detecting Down Syndrome and Neural Tube Defects in the Second Trimester of 87 Maternal Serum Samples, Based on 105-139 Days
Yiming Chen 12AEG** , Yijie Chen 2BE* , Yezhen Shi 3CD , Wenwen Ning 2BE , Xiaoying Wang 1B , Liyao Li 1BC , Huimin Zhang 2FDOI: 10.12659/MSM.935573
Med Sci Monit 2022; 28:e935573
Table 7 Comparison of screening efficiency of trisomy 21 and neural tube defects in different laboratories (%).
| Lab | Sensitivity | Specificity | PPV | NPV | FPR | FNR |
|---|---|---|---|---|---|---|
| T21 | ||||||
| Lab A | 75.00 | 96.15 | 50.00 | 98.68 | 3.85 | 25.00 |
| Lab B | 75.00 | 98.72 | 75.00 | 98.72 | 1.28 | 25.00 |
| Lab C | 75.00 | 98.72 | 75.00 | 98.72 | 1.28 | 25.00 |
| Lab D | 75.00 | 98.72 | 75.00 | 98.72 | 1.28 | 25.00 |
| Lab E | 75.00 | 98.72 | 75.00 | 98.72 | 1.28 | 25.00 |
| Lab F | 75.00 | 94.87 | 42.86 | 98.67 | 5.13 | 25.00 |
| NTD | ||||||
| Lab A | 60.00 | 100.00 | 100.00 | 97.50 | 0.00 | 40.00 |
| Lab B | 60.00 | 100.00 | 100.00 | 97.50 | 0.00 | 40.00 |
| Lab C | 20.00 | 100.00 | 100.00 | 95.12 | 0.00 | 80.00 |
| Lab D | 60.00 | 100.00 | 100.00 | 97.50 | 0.00 | 40.00 |
| Lab E | 60.00 | 100.00 | 100.00 | 97.50 | 0.00 | 40.00 |
| Lab F | 20.00 | 100.00 | 100.00 | 95.12 | 0.00 | 80.00 |
| Lab – laboratory; PPV – positive predictive value; NPV – negative predictive value; FPR – false positive rate; FNR – false negative rate; NTD – neural tube defects; T21 – trisomy 21. | ||||||