30 June 2022>: Clinical Research
Nomogram for Prediction of Postoperative Morbidity in Patients with Colon Cancer Requiring Emergency Therapy
Raul Mihailov 1ABCDEFG , Dorel Firescu 1AEF , Georgiana Bianca Constantin 2BDEF , Cristina Şerban 1BEF , Eugenia Panaitescu 3CDE , Cristian Marica 4BEF , Rodica Bîrlă 5ADEF* , Traian Patrascu 5DEFDOI: 10.12659/MSM.936303
Med Sci Monit 2022; 28:e936303
Table 1 Univariate analysis results of relationship between clinicopathological characteristics and postoperative complications in patients undergoing emergency surgery for complicated colon cancer.
PO COMPL=yes | PO COMPL=no | p value | ||
---|---|---|---|---|
Age | >68 years | 71/106 (67.0%) | 174/343 (50.7%) | * |
≤68 years | 35/106 (33.0%) | 169/343 (49.3%) | ||
SEX | F | 38/106 (35.8%) | 137/343 (39.9%) | * |
M | 68/106 (64.2%) | 206/343 (60.1%) | ||
DAVIES Score | 1 | 40/106 (37.7%) | 145/343 (42.3%) | # |
2 | 36/106 (34%) | 142/343 (41.4%) | ||
3 | 26/106 (24.5%) | 52/343 (15.2%) | ||
4 | 3/106 (2.8%) | 4/343 (1.2%) | ||
6 | 1/106 (0.9%) | 0/343 (0.0%) | ||
CHARLSON Score | ≤3 | 47/106 (44.3%) | 227/343 (66.2%) | * |
>3 | 59/106 (55.7%) | 116/343 (33.6%) | ||
Age-ajusted CHARLSON Score | ≤9 | 28/106 (26.4%) | 169/343 (49.3%) | * |
>9 | 78/106 (73.6%) | 174/343 (50.4%) | ||
Onset | ≤1 day | 5/106 (4.7%) | 24/343 (7.0%) | * |
2–5 days | 30/106 (28.3%) | 155/343 (45.2%) | ||
6–14 days | 57/106 (53.8%) | 136/343 (39.7%) | ||
>14 days | 14/106 (13.2%) | 28/343 (8.1%) | ||
ECOG | 0 | 8/106 (7.5%) | 75/343 (21,9%) | * |
1 | 14/106 (13.2%) | 60/343 (17.4%) | ||
2 | 45/106 (42.5%) | 137/343 (40%) | ||
3 | 20/106 (18.9%) | 57/343 (16.8%) | ||
4 | 19/106 (17.9%) | 14/343 (4.1%) | ||
Cachexia | Yes | 48/106 (45.3%) | 50/343 (14.6%) | * |
WBC | P | 81/106 (76.4%) | 122/343 (35.6%) | * |
Anemia | Yes | 86/106 (81.1%) | 210/343 (61.2%) | * |
Platelets | P | 33/106 (31.1%) | 33/343 (9.6%) | * |
Glycemia | P | 31/106 (29.2%) | 69/343 (20.0%) | * |
Creatinine | P | 64/106 (60.4%) | 113/343 (32.9%) | * |
Electrolyte disturbance | Yes | 54/106 (50.9%) | 81/343 (23.6%) | * |
Acidosis | Yes | 39/106 (36.8%) | 59/343 (17.2%) | * |
Coagulation disturbance | Yes | 28/106 (26.4%) | 25/343 (7.2%) | * |
Sepsis | Yes | 24/105 (22.9%) | 17/343 (5.0%) | * |
Preop diagnosis | H | 2/106 (1.9%) | 14/343 (4.1%) | * |
O | 75/106 (70.8%) | 301/343 (87.8%) | ||
P | 29/106 (27.4%) | 28/343 (8.2%) | ||
Location | C18.0 | 12/106 (11.3%) | 30/343 (8.7%) | * |
C18.2 | 6/106 (5.7%) | 14/343 (4.1%) | ||
C18.3 | 8/106 (7.5%) | 25/343 (7.2%) | ||
C18.4 | 13/106 (12.3%) | 28/343 (8.1%) | ||
C18.5 | 9/106 (8.5%) | 35/343 (10.1%) | ||
C18.6 | 9/106 (8.5%) | 38/343 (11%) | ||
C18.7 | 39/106 (36.8%) | 120/343 (35.0%) | ||
C19.0 | 10/106 (9.4%) | 53/343 (15.5%) | ||
IO COMPL | Yes | 17/106 (16.0%) | 30/343 (8.7%) | * |
Metastasis | Yes | 32/106 (30.2%) | 63/343 (18.4%) | * |
History of abdominal surgery | Yes | 44/106 (41.5%) | 103/343 (30.0%) | * |
Operation type | 1 | 13/106 (12.3%) | 60/343 (17.5%) | * |
2 | 41/106 (38.7%) | 128/343 (37.3%) | ||
3 | 12/106 (11.3%) | 29/343 (8.5%) | ||
4 | 40/106 (37.7%) | 126/343 (36.7%) | ||
Operating time | 1 h | 5/106 (4.7%) | 16/343 (4.7%) | * |
1.5 h | 10/106 (9.4%) | 56/343 (16.3%) | ||
2 h | 36/106 (34.0%) | 204/343 (59.5%) | ||
2.5 h | 25/106 (23.6%) | 35/343 (10.2%) | ||
3 h | 24/106 (22.6%) | 25/343 (7.3%) | ||
3.5 h | 2/106 (1.9%) | 1/343 (0.3%) | ||
4 h | 2/106 (1.9%) | 2/343 (0.6%) | ||
4.5 h | 1/106 (0.9%) | 1/343 (0.3%) | ||
5 h | 1/106 (0.9%) | 3/343 (0.9%) | ||
Abdominal closure | Open | 3/106 (2.8%) | 0/343 (0.0%) | * |
Closed | 94/106 (88.7%) | 340/343 (99.1%) | ||
Semi-open | 9/106 (8.5%) | 3/343 (0.9%) | ||
Antibiotic | 1 | 49/106 (46.2%) | 221/343 (64.4%) | * |
2 | 31/106 (29.2%) | 90/343 (26.1%) | ||
3 | 12/106 (11.3%) | 20/343 (5.8%) | ||
4 | 14/106 (13.2%) | 12/343 (3.5%) | ||
* Pearson chi-square; # likelihood ratio. PO COMPL – postoperative complications; Onset – duration from onset of symptoms to admission; ECOG – Eastern Cooperative Oncology Group performance status; WBC – white blood cell count; H – lower gastrointestinal hemorrhage; O – intestinal occlusion; P – peritonitis; C18.0 – cecum; C18.2 – ascending colon; C18.3 – hepatic flexure of colon; C18.4 – transverse colon; C18.5 – splenic flexure of colon; C18.6 – descending colon; C18.7 – sigmoid; C19 – rectosigmoid junction; IO COMPL – intraoperative complications; operation type 1 – colostomy; operation type 2 – colic resection with stoma; operation type 3 – internal by-pass; operation type 4 – colic resection with anastomosis; h – hours; P – pathologic value. |