13 October 2022: Clinical Research
Effects of Hemodilution on Clot Waveform Analysis Parameters, Clotting Factors, and Thrombin Generation Assays in a Dilutional Model Based on Analysis of 11 Healthy Male Blood Donors
Junko Ichikawa ABCDEG* , Ryouta Okazaki BC , Tomoki Fukuda B , Daejoon Yoon B , Makiko Komori DGDOI: 10.12659/MSM.937368
Med Sci Monit 2022; 28:e937368
Table 1 The correlation between aPTT-clot waveform analysis variables and thrombin generation parameters, aPTT-dependent coagulation factors, and fibrinogen.
| Clot time | Min1 | Min2 | Max2 | Delta | |
|---|---|---|---|---|---|
| Lag time | 0.057 | −0.305* | −0.232 | −0.259 | 0.591* |
| ETP | 0.014 | 0.274 | 0.289* | 0.244 | 0.806# |
| Peak | −0.192 | 0.773# | 0.642# | 0.635# | 0.952# |
| ttPeak | 0.094 | −0.206 | −0.172 | −0.201 | 0.481* |
| Fibrinogen | −0.634# | 0.958# | 0.938# | 0.935# | 0.978# |
| Factor II | −0.846# | 0.802# | 0.829# | 0.828# | 0.365* |
| Factor VIII | −0.666# | 0.769# | 0.785# | 0.776# | 0.344* |
| Factor IX | −0.789# | 0.882# | 0.897# | 0.898# | 0.443* |
| Factor X | −0.846# | 0.802# | 0.829# | 0.828# | 0.365* |
| aPTT – activated partial thromboplastin time; CWA – clot wave analysis; ETP – endogenous thrombin potential; ttPeak – time to peak; Min 1 – minimum value of the first derivative; Min2 – minimum value of the second derivative; Max2 – maximum peaks of the second derivative. * # | |||||