14 September 2022: Clinical Research
C-Reactive Protein/Albumin Ratio at Diagnosis of Pediatric Inflammatory Bowel Disease: A Retrospective Multi-Center Study
Aleksandra Glapa-Nowak 1ABCDEF , Mariusz Szczepanik 1ABE , Aleksandra Banaszkiewicz 2BE , Jarosław Kwiecień 3BE , Anna Szaflarska-Popławska 4BE , Urszula Grzybowska-Chlebowczyk 5BE , Marcin Osiecki 6BE , Jarosław Kierkuś 6BE , Marcin Dziekiewicz 2BE , Jarosław Walkowiak 1ACDEFG*DOI: 10.12659/MSM.937842
Med Sci Monit 2022; 28:e937842
Table 2 CRP/albumin ratio, C-reactive protein (CRP), and albumin concentrations depending on disease activity.
| Parameter median (1st–3rd quartile) | PCDAI | p value | |||
|---|---|---|---|---|---|
| Quiescentn=11 | Mildn=74 | Moderate n=47 | Severen=42 | ||
| CRP/albumin ratio at diagnosis | 0.02 (0.01–0.05) | 0.33 (0.05–0.79) | 0.38 (0.12–0.91) | 0.60 (0.31–1.80) | 0.011 |
| CRP at diagnosis [mg/l] | 0.8 (0.5–2.3) | 12.0 (2.0–28.3) | 14.4 (4.6–26.8) | 24.2 (12.9–49.5) | 0.007 |
| Albumin at diagnosis [g/dl] | 4.5 (4.2–4.7) | 4.0 (3.8–4.3) | 3.8 (3.4–4.2) | 3.7 (3.1–3.8) | 0.003 |
| CRP/albumin ratio at diagnosis | 0.29 (0.05–0.71) | 0.60 (0.31–1.80) | |||
| CRP at diagnosis [mg/l] | 11.8 (2.0–24.9) | 24.2 (12.9–49.5) | 0.041 | ||
| Albumin at diagnosis [g/dl] | 4.0 (3.7–4.3) | 3.7 (3.1–3.8) | 0.028 | ||
| CRP/albumin ratio at diagnosis | 0.11 (0.02–0.21) | 0.03 (0.01–0.09) | 0.09 (0.01–0.32) | 0.09 (0.00–0.36) | 0.353 |
| CRP at diagnosis [mg/l] | 4.6 (1.0–8.9) | 1.4 (0.5–3.8) | 3.8 (0.5–11.6) | 2.8 (0.2–14.2) | 0.429 |
| Albumin at diagnosis [g/dl] | 4.2 (4.1–4.3) | 4.4 (4.0–4.5) | 4.1 (3.7–4.3) | 4.0 (3.2–4.4) | 0.011 |
| CRP/albumin ratio at diagnosis | 0.05 (0.01–0.25) | 0.09 (0.01–0.36) | 0.906 | ||
| CRP at diagnosis [mg/l] | 2.2 (0.5–10.7) | 2.8 (0.2–14.2) | 0.856 | ||
| Albumin at diagnosis [g/dl] | 4.2 (3.8–4.4) | 4.0 (3.2–4.4) | 0.049 | ||
| CRP – C-reactive protein (reference values 0–5 mg/L); PUCAI– Pediatric Ulcerative Colitis Activity Index; PCDAI – Pediatric Crohn’s Disease Activity Index. | |||||