Association Between Nadir Hematocrit and Severe Acute Kidney Injury After Off-Pump Coronary Artery Bypass Graft Surgery: A Retrospective Cohort Study Based on the MIMIC-IV Database

03 November 2022: Database Analysis

Yisen Deng ^12ACE* , Bo Ma ^2DE* , Xuming Wang ^12DE* , Xueqiang Fan ^2BC , Qiangqiang Nie ^12B , Xixi Gao ^2B , Yuguang Yang ^2CE* , Peng Liu ^12CE*

DOI: 10.12659/MSM.937878

Med Sci Monit 2022; 28:e937878

Table 3 Subgroup analysis of the associations between hematocrit and severe acute kidney injury.

Subgroup	n	OR (95%CI)	P value	P for interaction
Age (y)				0.305
	1007.0	1 (0.87–1.15)	0.981
≥70	776.0	0.85 (0.74–0.97)	0.017
Sex, n (%)				0.644
Female	384.0	0.15 (0.02–1.09)	0.061
Male	1399.0	0.95 (0.85–1.05)	0.295
Race, n (%)				0.325
White	1249.0	0.96 (0.86–1.07)	0.467
Other	534.0	0.85 (0.72–1)	0.056
BMI (kg/m)				0.002
	982.0	0.77 (0.64–0.92)	0.005
≥30	801.0	0.97 (0.86–1.1)	0.611
Myocardial infarction				0.908
No	1073.0	0.9 (0.79–1.03)	0.131
Yes	710.0	0.89 (0.78–1.02)	0.097
Congestive heart failure				0.672
No	1416.0	0.89 (0.78–1.01)	0.075
Yes	367.0	0.95 (0.83–1.09)	0.49
Systolic BP (mm Hg)				0.808
	804.0	0.89 (0.8–1)	0.056
≥110	979.0	0.95 (0.79–1.14)	0.593
Diastolic BP (mm Hg)				0.124
	1212.0	0.87 (0.78–0.96)	0.007
≥60	571.0	0.99 (0.74–1.32)	0.945
Anion gap (mmol/L)				0.778
	797.0	0.89 (0.74–1.07)	0.22
≥13	986.0	0.93 (0.83–1.04)	0.187
Sodium (mmol/L)				0.196
	652.0	0.8 (0.61–1.05)	0.114
≥138	1131.0	0.94 (0.85–1.04)	0.204
Lactate (mmol/L)				0.982
	874.0	0.94 (0.79–1.12)	0.491
≥2.6	909.0	0.93 (0.83–1.04)	0.184
Epinephrine use				0.049
No	1443.0	0.93 (0.82–1.06)	0.304
Yes	340.0	0.88 (0.75–1.02)	0.092
Norepinephrine use				0.398
No	1503.0	0.9 (0.79–1.02)	0.098
Yes	280.0	1 (0.85–1.16)	0.949
Phenylephrine use				0.906
No	713.0	0.95 (0.84–1.08)	0.416
Yes	1070.0	0.9 (0.78–1.04)	0.141
SAPSII				0.129
	899.0	1.05 (0.82–1.34)	0.711
≥36	884.0	0.89 (0.8–0.99)	0.029
AKI – severe acute kidney injury; BMI – body mass index; BP – blood pressure; SAPSII – simplified acute physiology score II.