Clinicopathological Features of Breast Cancer in Relation to Exposure of Cycling Reproductive Hormones: A Multicenter Retrospective Study of 14,731 Patients Diagnosed with Invasive Breast Cancer

Jiazheng Sun; Jinxiang Tan; Hong Zheng; Jun Jiang; Tianning Zou; Hongyuan Li; Guosheng Ren; Dejuan Yang

doi:10.12659/MSM.938619

30 November 2022: Clinical Research

Clinicopathological Features of Breast Cancer in Relation to Exposure of Cycling Reproductive Hormones: A Multicenter Retrospective Study of 14 731 Patients Diagnosed with Invasive Breast Cancer

Jiazheng Sun ^1BE , Jinxiang Tan ^1BC , Hong Zheng ^2B , Jun Jiang ^3B , Tianning Zou ^4BC , Hongyuan Li ^1BF , Guosheng Ren ^1BC* , Dejuan Yang ^1AG*

DOI: 10.12659/MSM.938619

Med Sci Monit 2022; 28:e938619

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Background Material and Methods Results Discussion Conclusions References

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Table 2 Comparison of baseline characteristics between reproductive years <35 years and ≥35 years in patients with breast cancer.

Baseline characteristics	<35 yrs		≥35 yrs		Chi-square	P-value
Baseline characteristics	N	Percent	N	Percent	Chi-square	P-value
					16.45
Han	2306	95.41%	2882	96.91%
Uighur	45	1.86%	20	0.67%
Others	66	2.73%	72	2.42%
Unknown	0	0.00%	0	0.00%
Total	2417		2974
					5.54	0.1362
≤150	188	7.78%	266	8.94%
151–160	1013	41.91%	1277	42.94%
161–170	349	14.44%	383	12.88%
>170	7	0.29%	13	0.44%
Unknown	860	35.58%	1035	34.80%
Total	2417		2974
					0.71	0.8705
≤50	350	14.48%	430	14.46%
51–60	763	31.57%	949	31.91%
61–70	463	19.16%	603	20.28%
>70	180	7.45%	215	7.23%
Unknown	661	27.35%	777	26.13%
Total	2417		2974
BMI
	89	3.68%	80	2.69%	5.14	0.1621
18.5–23.9	781	32.31%	991	33.32%
24–27.9	499	20.65%	644	21.65%
≥28	185	7.65%	223	7.50%
Unknown	863	35.71%	1036	34.84%
Total	2417		2974
Marital status					1.91	0.3841
Married	2348	97.15%	2874	96.64%
Mever married/Single	7	0.29%	10	0.34%
Divorced/Widow	57	2.36%	88	2.96%
Unknown	5	0.21%	2	0.07%
Total	2417		2974
					5.16	0.1606
0	1506	62.31%	1937	65.13%
1	345	14.27%	405	13.62%
2	258	10.67%	288	9.68%
≥3	283	11.71%	312	10.49%
Unknown	25	1.03%	32	1.08%
Total	2417		2974
					13.89	0.0031
0	574	23.75%	682	22.93%
1	400	16.55%	608	20.44%
2	467	19.32%	569	19.13%
≥3	971	40.17%	1112	37.39%
Unknown	5	0.21%	3	0.10%
Total	2417		2974
					3.47	0.325
0	487	20.15%	570	19.17%
1	822	34.01%	1075	36.15%
2	553	22.88%	686	23.07%
≥3	553	22.88%	641	21.55%
Unknown	2	0.08%	2	0.07%
Total	2417		2974
					2.62	0.1052
	531	21.97%	524	17.62%
≥25	378	15.64%	434	14.59%
Unknown	1508	62.39%	2016	67.79%
Total	2417		2974
					725.03
≤12	140	5.79%	400	13.45%
13	350	14.48%	941	31.64%
14	477	19.74%	721	24.24%
15	435	18.00%	531	17.85%
16	389	16.09%	218	7.33%
≥17	626	25.90%	163	5.48%
Unknown	0	0.00%	0	0.00%
Total	2417		2974
					490.86
≤40	287	11.87%	0	0.00%
41–45	704	29.13%	1407	47.31%
46–50	1320	54.61%	1412	47.48%
51–55	106	4.39%	141	4.74%
56–60	0	0.00%	14	0.47%
>60	0	0.00%	0	0.00%
Unknown	0	0.00%	0	0.00%
Total	2417		2974
					5.82
No	1526	63.14%	2019	67.89%
Yes	29	1.20%	19	0.64%
Unknown	862	35.66%	936	31.47%
Total	2417		2974
					147.31
No	1365	56.47%	1966	66.11%
Yes	250	10.34%	80	2.69%
Unknown	802	33.18%	928	31.20%
Total	2417		2974
					2.02	0.1556
No	1820	75.30%	2338	78.61%
Yes	199	8.23%	221	7.43%
Unknown	398	16.47%	415	13.95%
Total	2417		2974

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Clinicopathological Features of Breast Cancer in Relation to Exposure of Cycling Reproductive Hormones: A Multicenter Retrospective Study of 14 731 Patients Diagnosed with Invasive Breast Cancer

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