06 February 2023>: Database Analysis
Comparison of Neonatal Morbidity and Mortality Following Spontaneous and Medically Indicated Preterm Births: A Retrospective Population-Based Study Using Data from the Slovenian National Perinatal Information System 2013–2018
Katja Čehovin 1DEF* , Ajda Gortnar 2DEF* , Ivan Verdenik 3ABCD , Miha Lučovnik 34ACDE , Lilijana Kornhauser-Cerar 3ACDE , Štefan Grosek 356ACDEFG*DOI: 10.12659/MSM.938941
Med Sci Monit 2023; 29:e938941
Table 2 Neonatal outcomes according to type of preterm birth at GA 22 0/7 to 36 6/7 weeks.
Spontaneous preterm birth N (%) | Medically indicated preterm birth N (%) | OR (95% CI)* | Adjusted OR (95% CI) multivariate analysis** | |
---|---|---|---|---|
Neonatal mortality | 43 (0.7%) | 23 (0.8%) | 0.88 [0.53–1.46] | 0.56 [0.26–1.20] |
IVH | 62 (1.0%) | 11 (0.4%) | 2.67 [1.41–5.09] | 1.01 [0.43–2.33] |
cPVL | 24 (0.4%) | 10 (0.3%) | 1.13 [0.54–2.37] | 0.68 [0.27–1.73] |
BPD | 162 (2.6%) | 69 (2.3%) | 1.11 [0.83–1.48] | 0.81 [0.52–1.26] |
NEC | 41 (0.7%) | 24 (0.8%) | 0.80 [0.49–1.33] | 0.55 [0.27–1.15] |
LOS | 58 (0.9%) | 16 (0.5%) | 1.72 [0.99–2.99] | 1.93 [0.92–4.06] |
ROP | 79 (1.3%) | 35 (1.2%) | 1.07 [0.71–1.59] | 0.33 [0.17–0.63] |
Composite neonatal morbidity | 298 (4.8%) | 120 (4.1%) | 1.18 [0.95–1.47] | 0.76 [0.54–1.08] |
IVH – intraventricular hemorrhage (Papile grade 3 or 4); cPVL – cystic periventricular leukomalacia; BPD – bronchopulmonary dysplasia; NEC – necrotizing enterocolitis; LOS – late-onset neonatal sepsis; ROP – retinopathy of prematurity, composite neonatal morbidity defined as any of the conditions above. * Univariate analysis odds ratio. ** Multivariate analysis odds ratio: Adjusted for small for gestational age (SGA – defined as neonatal weight 37 years, maternal body-mass-index (BMI) >30 kg/m, and in vitro fertilization (IVF). |