28 March 2024: Clinical Research
Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Predicting Complete Pathological Response in Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy
Mustafa Karaca 1ACDEF* , Ece Salim 2ABDEF , Mustafa Serkan Alemdar 3BDEF , Özge Deniz Karaca 2BEF , Mustafa Özgür Arıcı 3BDEFDOI: 10.12659/MSM.943750
Med Sci Monit 2024; 30:e943750
Table 7 Factors associated with overall survival of patients.
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| Age | 1.035 (1.004–1.068) | 1.04 (1.007–1.073) | ||
| Male gender | 1.312 (0.683–2.519) | 0.415 | ||
| Comorbid disease | 0.538 (0.27–1.071) | 0.078 | 0.474 (0.234–1.018) | 0.065 |
| Chemotherapy agent | ||||
| Capecitabine | Reference | – | Reference | – |
| 5-FU | 2.097 (1.104–3.982) | 2.188 (1.129–4.238) | ||
| Type of surgery | ||||
| LAR | Reference | – | Reference | – |
| MILES operation | 2.347 (1.239–4.446) | 0.009 | 2.11 (1.097–4.055) | |
| Hemoglobin at diagnosis | 0.904 (0.78–1.048) | 0.904 | – | – |
| Platelets at diagnosis | 1 (0.996–1.003) | 0.853 | – | – |
| LDH at diagnosis | 1.003 (0.998–1.009) | 0.246 | – | – |
| NLR at diagnosis >3.63 | 1.724 (0.934–3.181) | 0.082 | 1.144 (0.604–2.167) | 0.680 |
| HR – hazard ratio; CI – confidence interval; 5-FU – 5-Fluorouracil; LAR – low anterior resection; LDH – lactate dehydrogenase; NLR – neutrophil/lymphocyte ratio. | ||||