24 March 2021: Database Analysis
Genome-Scale Analysis Identified , , and as Prognosis Markers of Overall Survival in Gastric Cancer
Zexing Shan ACDE , Wentao Wang B , Yilin Tong B , Jianjun Zhang B*DOI: 10.12659/MSM.929558
Med Sci Monit 2021; 27:e929558
Table 3 KEGG pathway enrichment analysis of the 144 differentially expressed genes.
| Category | Term | Count | P value | FDR | Genes |
|---|---|---|---|---|---|
| KEGG_PATHWAY | hsa04512: ECM-receptor interaction | 14 | 3.93E-12 | 4.53E-09 | COL4A2, COL4A1, COL3A1, COL2A1, COL5A2, COL5A1, COL6A3, COL1A2, COL1A1, THBS1, COL11A1, THBS2, SPP1, FN1 |
| KEGG_PATHWAY | hsa04974: Protein digestion and absorption | 12 | 1.48E-09 | 1.70E-06 | COL4A2, COL4A1, COL3A1, COL6A3, COL1A2, CPA2, COL2A1, COL1A1, COL11A1, COL5A2, COL5A1, COL10A1 |
| KEGG_PATHWAY | hsa04510: Focal adhesion | 15 | 2.34E-08 | 2.69E-05 | COL4A2, COL4A1, COL3A1, COL2A1, COL5A2, COL5A1, COL6A3, COL1A2, PDGFD, COL1A1, THBS1, COL11A1, THBS2, SPP1, FN1 |
| KEGG_PATHWAY | hsa05146: Amoebiasis | 11 | 1.36E-07 | 1.57E-04 | COL4A2, COL4A1, COL3A1, COL1A2, CXCL8, COL2A1, COL1A1, COL11A1, COL5A2, COL5A1, FN1 |
| KEGG_PATHWAY | hsa04978: Mineral absorption | 7 | 5.95E-06 | 0.006851 | MT1M, MT2A, MT1E, MT1H, MT1X, MT1G, MT1F |
| KEGG_PATHWAY | hsa04151: PI3K-Akt signaling pathway | 15 | 1.22E-05 | 0.014013 | COL4A2, COL4A1, COL3A1, COL2A1, COL5A2, COL5A1, COL6A3, COL1A2, PDGFD, COL1A1, THBS1, COL11A1, THBS2, SPP1, FN1 |
| KEGG_PATHWAY | hsa04971: Gastric acid secretion | 7 | 1.13E-04 | 0.129558 | KCNJ16, KCNJ15, CCKBR, ATP4A, ATP4B, KCNE2, CA2 |
| KEGG_PATHWAY | hsa04611: Platelet activation | 8 | 4.23E-04 | 0.486191 | COL3A1, COL1A2, FCER1G, COL2A1, COL1A1, COL11A1, COL5A2, COL5A1 |
| KEGG_PATHWAY | hsa00982: Drug metabolism – cytochrome P450 | 6 | 7.27E-04 | 0.833392 | GSTA1, FMO5, MAOA, ADH1C, UGT2B15, ALDH3A1 |
| KEGG_PATHWAY | hsa00980: Metabolism of xenobiotics by cytochrome P450 | 6 | 0.001069 | 1.223788 | GSTA1, ADH1C, AKR7A3, UGT2B15, AKR1C1, ALDH3A1 |
| KEGG_PATHWAY | hsa05204: Chemical carcinogenesis | 5 | 0.010061 | 10.99085 | GSTA1, CYP2C18, ADH1C, UGT2B15, ALDH3A1 |
| KEGG_PATHWAY | hsa00340: Histidine metabolism | 3 | 0.022373 | 22.93516 | HDC, MAOA, ALDH3A1 |
| KEGG_PATHWAY | hsa00830: Retinol metabolism | 4 | 0.030117 | 29.67766 | ALDH1A1, CYP2C18, ADH1C, UGT2B15 |
| KEGG_PATHWAY | hsa04966: Collecting duct acid secretion | 3 | 0.032861 | 31.93507 | ATP4A, ATP4B, CA2 |