12 April 2022>: Clinical Research
Development and Validation of a Nomogram for Predicting Postoperative Distant Metastasis in Patients with Cervical Cancer
Weihong Zeng ABCDE , Lishan Huang BCD , Haihong Lin BCD , Ru Pan BCD , Haochang Liu BCD , Jizhong Wen BCD , Ye Liang BCD , Haikun Yang AE*DOI: 10.12659/MSM.933379
Med Sci Monit 2022; 28:e933379
Table 2 Results of univariate analysis in the training set.
Variables | Training set | Statistics | P | |
---|---|---|---|---|
Non-metastasis (n=4305) | Metastasis (n=190) | |||
Age at diagnosis (years), Mean±SD | 46.96±12.39 | 51.28±12.38 | t=−4.700 | |
Histologic type, n (%) | χ=30.512 | |||
Squamous cell carcinoma | 2460 (57.14) | 83 (43.68) | ||
Adenocarcinoma | 758 (17.61) | 25 (13.16) | ||
Adenosquamous carcinoma | 209 (4.85) | 17 (8.95) | ||
Other | 878 (20.39) | 65 (34.21) | ||
Grade, n (%) | Z=7.568 | |||
I | 1968 (45.71) | 65 (34.21) | ||
II | 1383 (32.13) | 103 (54.21) | ||
III | 104 (2.42) | 11 (5.79) | ||
IV | 850 (19.74) | 11 (5.79) | ||
T stage, n (%) | Z=17.479 | |||
T1 | 3552 (82.51) | 65 (34.21) | ||
T2 | 616 (14.31) | 67 (35.26) | ||
T3 | 115 (2.67) | 46 (24.21) | ||
T4 | 22 (0.51) | 12 (6.32) | ||
N stage, n (%) | χ=321.426 | |||
N0 | 3645 (84.67) | 65 (34.21) | ||
N1 | 660 (15.33) | 125 (65.79) | ||
Treatment, n (%) | χ=328.799 | |||
Surgery | 2430 (56.45) | 24 (12.63) | ||
Surgery+chemotherapy | 118 (2.74) | 46 (24.21) | ||
Surgery+radiotherapy | 465 (10.80) | 17 (8.95) | ||
Surgery+radiotherapy+chemotherapy | 1292 (30.01) | 103 (54.21) | ||
Tumor size (cm), n (%) | χ=175.142 | |||
3245 (75.38) | 61 (32.11) | |||
≥4 | 1060 (24.62) | 129 (67.89) | ||
First malignant primary, n (%) | χ=5.301 | 0.021 | ||
No | 204 (4.74) | 16 (8.42) | ||
Yes | 4101 (95.26) | 174 (91.58) | ||
Number of lymph node, M (Q, Q) | 13.00 (0.00, 22.00) | 5.00 (0.00, 16.00) | Z=−4.874 | |
Regional nodes positive, n (%) | χ=131.388 | |||
No | 2615 (60.74) | 36 (18.95) | ||
Yes | 1690 (39.26) | 154 (81.05) | ||
SD – standard deviation; M – median. |