21 June 2022: Clinical Research
Prognostic Significance of Preoperative Integrated Liver Inflammatory Score in Patients with Hepatocellular Carcinoma
Biao Wu 12ABCDEF* , Yumeng Wu 2ABC* , Xianlin Guo 12BCF , Yifei Liu 3ACD , Yanping Yue 2BCF , Wenjing Zhao 2ABG , Jibin Liu 2ADG , Xuming Wu 4ABC , Aiguo Shen 2ACEG* , Suqing Zhang 1ACEFG*DOI: 10.12659/MSM.937005
Med Sci Monit 2022; 28:e937005
Table 3 Univariate and multivariate analyses of prognostic factors with RFS in patients with HCC.
| Variable | Training cohort | |||
|---|---|---|---|---|
| Univariate | Multivariate | |||
| HR (95% CI) | P | HR (95% CI) | P | |
| ILIS (high vs low) | 1.869 (1.131–3.059) | |||
| Age ( | 1.434 (0.893–2.302) | 0.136 | ||
| Gender ( male vs female) | 0.684 (0.396–1.180) | 0.172 | ||
| HBV (absent vs present) | 0.661 (0.415–1.054) | 0.082 | ||
| Cirrhosis (absent vs present) | 0.581 (0.364–0.925) | |||
| Tumour size (10 cm) | 2.048 (1.479–2.837) | 0.448 (0.225–0.892) | ||
| No. of tumour nodules (1 vs ≥2) | 1.517 (0.845–2.723) | 0.163 | ||
| Differentiation (well vs moderate vs poor) | 1.505 (1.073–2.109) | |||
| Vascular tumor thrombus (absent vs present) | 2.295 (1.423–3.701) | 0.506 (0.311–0.823) | ||
| Child-Pugh class (A vs B) | 0.657 (0.285–1.519) | 0.326 | ||
| BCLC stage (0 vs A vs B) | 0.348 (0.196–0.617) | 0.457 (0.251–0.834) | ||
| ILIS (high vs low) | 3.566 (1.694–7.507) | |||
| Age ( | 0.821 (0.367–1.834) | 0.630 | ||
| Gender ( male vs female) | 1.887 (0.645–5.524) | 0.246 | ||
| HBV (absent vs present) | 0.906 (0.402–2.043) | 0.813 | ||
| Cirrhosis (absent vs present) | 0.954 (0.423–2.149) | 0.909 | ||
| Tumour size (10 cm) | 2.205 (1.221–3.983) | |||
| No. of tumour nodules (1 vs ≥2) | 2.358 (0.554–10.004) | 0.246 | ||
| Differentiation (well vs moderate vs poor) | 1.137 (0.606–2.134) | 0.689 | ||
| Vascular tumor thrombus (absent vs present) | 3.384 (1.477–7.750) | |||
| Child-Pugh class (A vs B) | 0.383 (0.130–1.124) | 0.080 | ||
| BCLC stage (0 vs A vs B) | 0.280 (0.116–0.676) | 0.247 (0.065–0.931) | ||